Prognostic Value of CALLY Index, Frailty and SOFA-2 Score for Mortality in Geriatric Intensive Care Patients: A Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 138
- 试验地点
- 1
研究概览
简要总结
This study aims to evaluate the prognostic value of the C-reactive protein-albumin-lymphocyte (CALLY) index, Clinical Frailty Scale (CFS), and SOFA-2 score in predicting mortality among geriatric intensive care unit (ICU) patients.
The primary outcome is ICU mortality. Secondary outcomes include 28-day mortality, ICU length of stay, duration of mechanical ventilation, need for renal replacement therapy, and vasopressor requirement.
The study also investigates whether the combined use of these parameters improves predictive performance compared to conventional scoring systems such as APACHE II.
详细描述
This is a single-center, prospective observational cohort study including patients aged ≥65 years admitted to the intensive care unit.
Demographic characteristics, comorbidities, frailty status (Clinical Frailty Scale), and severity scores (SOFA-2, APACHE II) will be recorded. Laboratory parameters including C-reactive protein, albumin, and lymphocyte count will be used to calculate the CALLY index within the first 24 hours of ICU admission.
Patients will be followed for ICU mortality and 28-day mortality. Additional outcomes include ICU and hospital length of stay, duration of mechanical ventilation, vasopressor requirement, and need for renal replacement therapy.
Statistical analyses will include logistic regression and receiver operating characteristic (ROC) curve analysis to evaluate the predictive performance of each parameter and their combined use.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥65 years
- •Admission to the intensive care unit
- •Availability of required clinical and laboratory data within the first 24 hours of ICU admission
排除标准
- •Death within the first 24 hours after ICU admission
- •Missing key clinical or laboratory data
- •Terminal malignancy receiving palliative care
研究组 & 干预措施
Geriatric ICU patients
Geriatric patients (aged ≥65 years) admitted to the intensive care unit will be included as a single observational cohort. All participants will be evaluated for CALLY index, frailty status, and SOFA-2 score within the first 24 hours of ICU admission.
干预措施: observational study (Other)
研究者
tugba yesilyurt dogu
Specialist in Anesthesiology and Intensive Care
Başakşehir Çam & Sakura City Hospital