NL-OMON37385
Completed
Not Applicable
The role of humoral autoimmunity in the aetiology of achalasia. - Antibodies in achalasia.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Achalasia
- Sponsor
- Academisch Medisch Centrum
- Enrollment
- 400
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with achalasia:
- •\- Diagnosis of achalasia confirmed by:
- •\- Oesophageal manometry; aperistalsis, LOS dysrelaxation and hypertensive LOS (\>10mmHg).
- •\- Barium oesophagogram; delayed emptying, aperistalsis and dilatation of the oesophagus with narrowing of the distal oesophagus.
- •\- Eckhardt score \* 2\.
- •\- Age 18\-75 years.
- •\- Written informed consent;Healthy controls:
- •\- Age 18\-75 years.
- •\- Written informed consent
Exclusion Criteria
- •Patients with achalasia:
- •\- Pseudoachalasia
- •\- Chagas disease
- •\- Upper gastrointestinal malignancy;Healthy controls:
- •\- Symptoms suggestive of oesophageal disease.
- •\- History of malignancy.
- •\- History of diseases affecting the upper gastrointestinal tract (gastro\-oesophageal reflux disease, eosinophilic oesophagitis)
- •\- Pseudoachalasia
- •\- Chagas disease
- •\- Autoimmune diseases
Outcomes
Primary Outcomes
Not specified
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