Effect of RVX000222 on Time to Major Adverse Cardiovascular Events in High-Risk T2DM Subjects With CAD
- Conditions
- Diabetes Mellitus, Type 2Coronary Artery Disease
- Interventions
- Registration Number
- NCT02586155
- Lead Sponsor
- Resverlogix Corp
- Brief Summary
The purpose of this study is to determine whether bromodomain extraterminal domain (BET) inhibition treatment with RVX000222 in high-risk type 2 diabetes mellitus patients with coronary artery disease increases the time to major adverse cardiovascular events.
- Detailed Description
The majority (75%) of deaths in subjects with diabetes mellitus (DM) are due to atherosclerotic cardiovascular disease (CVD). Recent studies suggest a major adverse cardiovascular event (MACE) rate of \>11% over 18 months in type 2 diabetes mellitus (T2DM) despite a baseline LDL-C of \<2.1 mmol/L. Bromodomains (BRDs) are a family of evolutionary conserved protein-interaction modules that play key functions in chromatin organization and regulation of gene transcription. One recognized family of bromodomain-containing proteins is the bromodomain and extra-terminal (BET) family. BET inhibition represents a novel, epigenetic approach to treat CAD.
RVX000222 affects biological processes important in atherosclerosis and acute coronary events via selective inhibition of BET proteins. RVX000222 is available as a capsule formulation with standard excipients and established stability.
The BETonMACE study will focus on prevention of subsequent MACE in subjects with CAD and DM with high intensity statin therapy as co-medication.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 2425
• ACS event of either unstable angina or myocardial infarction 7-90 days prior Visit 1:
Unstable angina: for a qualifying unstable angina event, each of components (a), (b), and (c) must be satisfied: a.) Characteristic ischemic pain or discomfort in chest/associated referral areas, occurring at rest/with minimal exertion b.) ECG changes consistent with acute myocardial ischemia based on new/presumed ST elevation/depression or T-wave inversion c.) Objective evidence of obstructive CAD based on 1+ of the following: i. New/presumed new evidence of myocardial ischemia/infarction by perfusion imaging ii. New/presumed new regional wall motion abnormality iii. Current evidence of at least 1 epicardial coronary artery stenosis ≥70% by coronary angiography iv. Need for coronary revascularization for the index ACS event, including a percutaneous coronary intervention (PCI) with or without coronary stenting.
Prior MI 7-90 days prior screening treated with or without a percutaneous coronary intervention (PCI). For a qualifying event of MI 2 of the following 3 criteria must be satisfied: a.) Characteristic ischemic chest pain/pain in associated referral areas b.) Dynamic elevation of troponin T/I or CKMB if troponinT/I is unavailable at local lab (at least >ULN for lab) c.) Development of new Q-waves in ≥2 adjacent ECG leads or development of new dominant R wave in V1
- Documented diagnosis of T2DM (1+ of the following criteria): Documented history of T2DM, History of taking diabetes medication, and/or HbA1c ≥6.5% at Visit 1
- For males HDL-C<40 mg/dL(1.04 mmol/L), for females HDL-C<45 mg/dL(1.17 mmol/L) at Visit 1
- Subjects currently not on high intensity statin therapy could start rosuvastatin at Visit 1 and those currently on therapy besides atorvastatin/rosuvastatin can be switched to rosuvastatin at Visit 1
- Female subjects of non-childbearing potential (post-surgical sterilization/post-menopausal) or if childbearing potential have neg urine pregnancy test and be willing and able to use non-hormonal birth control (non-hormonal IUD, condom or diaphragm) or remain abstinent from Screening to Follow-up Visit
- Give signed informed consent
- Heart disease which will w/in 90 days of Visit 1 likely need coronary bypass, PCI, cardiac transplantation, surgical repair and/or replacement
- Previous/current diagnosis of severe heart failure or documented LVEF<25% determined by contrast left ventriculography, radionuclide ventriculography or echocardiography. Absence of LVEF measurement in subject w/out a previous/current diagnosis of heart failure does not exclude entry into study
- Evidence of cardiac EP instability incl. history of uncontrolled ventricular arrhythmias, atrial fibrillation/flutter or supraventricular tachycardias w/ a ventricular response HR>100bpm at rest w/in 4 wks prior Visit 1
- CABG w/in 90 days prior Visit 1
- Evidence of severe renal impairment as determined by either eGFR<30 mL/min/1.7m2 at Visit 1 or current need for dialysis
- Uncontrolled hypertension defined as 2 consecutive measurements of sitting BP of systolic>180 mmHg or diastolic>100 mmHg at Visit 1
- Treatment w/ immunosuppressants w/in 12 mos prior Visit 1
- Use of fibrates at any dose or niacin/nicotinic acid 250+ mg w/in 30 days prior Visit 1
- Known allergy/sensitivity to any ingredient in IMP
- History of intolerance to atorvastatin/rosuvastatin
- Triglycerides>400 mg/dL (4.52 mmol/L) at Visit 1
- Any medical/surgical condition which might significantly alter absorption, distribution, metabolism or excretion of medication
- Evidence of cirrhosis from liver imaging/biopsy, history of hepatic encephalopathy, esophageal/gastric varices, active hepatitis or prior porta-caval shunt procedure or a Child-Pugh score of ≥5 points
- ALT/AST>1.5xULN by central lab at Visit 1
- Tot. bilirubin>ULN by central lab at Visit 1
- History of malignancy of any organ syst treated/untreated w/in the past 2 yrs whether or not there is evidence of local recurrence/metastases except localized basal skin cell carcinoma
- History/evidence of drug/alcohol abuse w/in 12 mos of Visit 1
- Pregnancy
- Any condition which may place subject at higher risk from his/her participation in the study or is likely to prevent subject from completing/complying w/ requirements of study
- Use of other investigational drugs and devices w/in 30 days or 5 half-lives of Visit 1, whichever is longer
- History of noncompliance to medical regimens or unwillingness to comply w/ study protocol
- Any condition that would confound the evaluation/interpretation of efficacy and/or safety data
- Persons directly involved in execution of this protocol
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description High-Intensity statin therapy+RVX000222 Atorvastatin Daily dose 100 mg capsule b.i.d. with high-intensity statin therapy (atorvastatin or rosuvastatin) High-Intensity statin therapy+Placebo Placebo Placebo (for RVX000222 100 mg capsule) b.i.d. with high-intensity statin therapy (atorvastatin or rosuvastatin) High-Intensity statin therapy+RVX000222 Apabetalone Daily dose 100 mg capsule b.i.d. with high-intensity statin therapy (atorvastatin or rosuvastatin) High-Intensity statin therapy+RVX000222 Rosuvastatin Daily dose 100 mg capsule b.i.d. with high-intensity statin therapy (atorvastatin or rosuvastatin) High-Intensity statin therapy+Placebo Atorvastatin Placebo (for RVX000222 100 mg capsule) b.i.d. with high-intensity statin therapy (atorvastatin or rosuvastatin) High-Intensity statin therapy+Placebo Rosuvastatin Placebo (for RVX000222 100 mg capsule) b.i.d. with high-intensity statin therapy (atorvastatin or rosuvastatin)
- Primary Outcome Measures
Name Time Method Incidence of First Occurrence of Adjudication-confirmed Narrowly Defined MACE 120 weeks Incidence of first occurrence of MACE narrowly defined as a single composite endpoint of Cardiovascular (CV) Death (including undetermined cause of death) or Non-fatal Myocardial Infarction (MI) or Stroke. If a subject has multiple events, only the first event contributing to the composite endpoint is counted.
- Secondary Outcome Measures
Name Time Method Incidence of First Occurrence of Adjudication-confirmed Broadly Defined MACE 120 weeks First occurrence of MACE broadly defined as a single composite endpoint of Cardiovascular Death (CVD) (including undetermined cause of death) or Non-fatal Myocardial Infarction (MI), Stroke, or Hospitalization for CVD events (including unstable angina and evidence of new or presumed new progressive obstructive coronary disease or emergency revascularization procedures at any time and urgent revascularization procedures ≥30 days after the index event as defined by Hicks et al., 2014) . If a subject has multiple events, only the first event contributing to the composite endpoint is counted.
Incidence of Hospitalization for Congestive Heart Failure (CHF) 120 weeks Change in Estimated Glomerular Filtration Rate (eGFR) From Baseline Over Time Within and Between Treatment Groups for Subjects With Impaired Renal Function at Baseline (eGFR <60 mL/Min/1.7m2) 120 weeks Incidence of All-cause Mortality 120 weeks Change in Apolipoprotein B (apoB) Concentration From Baseline Over Time Within and Between Treatment Groups 120 weeks Change in Hemoglobin (Hb) A1c From Baseline Over Time Within and Between Treatment Groups 120 weeks Change in Apolipoprotein A1 (ApoA-I) Concentration From Baseline Over Time Within and Between Treatment Groups 120 weeks Change in LDL-C Concentration From Baseline Over Time Within and Between Treatment Groups 120 weeks Change in HDL-C Concentration From Baseline Over Time Within and Between Treatment Groups 120 weeks Change in Triglyceride (TG) Concentration From Baseline Over Time Within and Between Treatment Groups 120 weeks Change in C Reactive Protein (CRP) Concentration From Baseline Over Time Within and Between Treatment Groups 52 weeks Change in Glucose From Baseline Over Time Between and Within Treatment Groups 120 weeks Change in Alkaline Phosphatase (ALP) From Baseline Over Time Within and Between Treatment Groups 172 weeks
Trial Locations
- Locations (213)
Clinical Hospital Sveti duh
🇭🇷Zagreb, Croatia
AZ Turnhout
🇧🇪Turnhout, Belgium
Kaplan Medical Center
🇮🇱Rehovot, Israel
Studienzentrum Dr.Appel
🇩🇪Kassel, Germany
ZNA Middelheim
🇧🇪Antwerpen, Belgium
Instituto Cardiovascular de Buenos Aires
🇦🇷Buenos Aires, Argentina
Centro Médico Colón
🇦🇷Córdoba, Argentina
Multiprofile Hospital For Active Treatment - Dr. Bratan Shukerov AD
🇧🇬Smolyan, Bulgaria
Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda
🇧🇬Sofia, Bulgaria
University Multiprofile Hospital for Active Treatment Aleksandrovska EAD
🇧🇬Sofia, Bulgaria
Instituto de Investigaciones Clinicas Bahia Blanca
🇦🇷Bahía Blanca, Argentina
Centro Privado de Enfermedades Cardiovasculares
🇦🇷Buenos Aires, Argentina
Sanatorio Guemes
🇦🇷Buenos Aires, Argentina
Flinders Medical Centre
🇦🇺Bedford Park, Australia
Second Multiprofile Hospital for Active Treatment Sofia
🇧🇬Sofia, Bulgaria
Medical Center Orfey OOD
🇧🇬Stara Zagora, Bulgaria
DRK Kliniken Berlin Westend
🇩🇪Berlin, Germany
Bioclinica Buenos Aires
🇦🇷Buenos Aires, Argentina
Centro Médico Luquez
🇦🇷Córdoba, Argentina
Asklepios Klinik Langen
🇩🇪Langen, Germany
Clinical Hospital Osijek
🇭🇷Osijek, Croatia
Clinica Coronel Suarez
🇦🇷Coronel Suárez, Argentina
Sanatorio Allende
🇦🇷Córdoba, Argentina
Hospital Cordoba
🇦🇷Córdoba, Argentina
Instituto Modelo de Cardiologia
🇦🇷Córdoba, Argentina
Multiprofile Hospital For Active Treatment Dr Tota Venkova
🇧🇬Gabrovo, Bulgaria
Heidelberger Praxisklinik für Kardiologie
🇩🇪Heidelberg, Germany
General Hospital Karlovac
🇭🇷Karlovac, Croatia
Special Hospital for medicinal rehabilitation Krapinske Toplice
🇭🇷Krapinske Toplice, Croatia
Imelda VZW
🇧🇪Bonheiden, Belgium
Consultorios Asociados Endocronología E Investigación Clínica Aplicada
🇦🇷Buenos Aires, Argentina
Hospital San Roque
🇦🇷Córdoba, Argentina
Multiprofile Hospital For Active Treatment - Pazardzhik AD
🇧🇬Pazardzhik, Bulgaria
Klinikum Hoyerswerda
🇩🇪Hoyerswerda, Germany
Unidad de Investigacion Clinica Cardiometabolica de Occidente SC
🇲🇽Guadalajara, Mexico
General Hospital Virovitica
🇭🇷Virovitica, Croatia
Polsko-Amerykanskie Kliniki Serca
🇵🇱Nysa, Poland
Szpital Specjalistyczny im. Jozefa Dietla w Krakowie
🇵🇱Kraków, Poland
City Clinic University Multiprofile Hospital for Active Treatment EOOD
🇧🇬Sofia, Bulgaria
Medical Center Kardiohelp EOOD
🇧🇬Sofia, Bulgaria
Medizinisches Versorgungszentrum am Küchwald GmbH
🇩🇪Chemnitz, Germany
Katholisches Krankenhaus St. Johann Nepomuk
🇩🇪Erfurt, Germany
Rodzinne Centrum Zdrowia
🇵🇱Otwock, Poland
Del-pesti Centrumkorhaz- Orszagos Hematologiai és Infektologiai Intezet
🇭🇺Budapest, Hungary
Investigacion en Salud y Metabolismo S.C.
🇲🇽Chihuahua, Mexico
Fundación de Atención e Investigación Médica Lindavista S.C.
🇲🇽Ciudad de México, Mexico
Malopolskie Centrum Sercowo-Naczyniowe
🇵🇱Chrzanow, Poland
VU Medisch Centrum
🇳🇱Amsterdam, Netherlands
Pro Corde, Dom Medyczny
🇵🇱Opole, Poland
TaNaMed Kft.
🇭🇺Mosonmagyaróvár, Hungary
Edith Wolfson Medical Center
🇮🇱Holon, Israel
Meir Medical Center
🇮🇱Kefar-Sava, Israel
Galilee Medical Center
🇮🇱Nahariya, Israel
Hadassah University Hospital Mount Scopus
🇮🇱Jerusalem, Israel
Clinica Integral del Paciente Diabetico y Obeso
🇲🇽Ciudad De México, Mexico
Unidad de Investigación Clínica En Medicina SC
🇲🇽Monterrey, Mexico
Niepubliczny Zaklad Opieki Zdrowotnej Centrum Uslug Medycznych Promont-Med.
🇵🇱Kielce, Poland
Soroka University Medical Centre
🇮🇱Be'er Sheva, Israel
Linn Medical Center Clalit Health Services
🇮🇱Haifa, Israel
Clalit Health Medical Center
🇮🇱Tel Aviv, Israel
City Hospital 13
🇷🇺Nizhniy Novgorod, Russian Federation
Centro de Investigación Biomedica y Farmaceutica
🇲🇽Ciudad de México, Mexico
Podlaski Osrodek Kardiologii Poradnia Prywatna
🇵🇱Bialystok, Poland
Diamond Clinic
🇵🇱Kraków, Poland
Zespol Przychodni Specjalistycznych DIAB-END-COR Sp. z o.o.
🇵🇱Kraków, Poland
Chaim Sheba Medical Center
🇮🇱Ramat Gan, Israel
Meander Medisch Centrum
🇳🇱Amersfoort, Netherlands
Hospital Cardiológica Aguascalientes
🇲🇽Aguascalientes, Mexico
Instituto Cardiovascular de Monclova
🇲🇽Monclova, Mexico
Centrum Medyczne doktorA
🇵🇱Warszawa, Poland
Kanizsai Dorottya Kórház
🇭🇺Nagykanizsa, Hungary
Bnei Zion Medical Center
🇮🇱Haifa, Israel
ZIV Medical Center
🇮🇱Safed, Israel
Cardioinvest s. r. o.
🇸🇰Nove Zamky, Slovakia
Niepubliczny Zaklad Opieki Zdrowotnej Specjalistyczna Przychodnia Lekarska "MEDIKARD"
🇵🇱Plock, Poland
Clinical Centre of Vojvodina
🇷🇸Novi Sad, Serbia
St Petersburg City Outpatient Clinic #109
🇷🇺Saint Petersburg, Russian Federation
KARDIOMED s.r.o.
🇸🇰Lucenec, Slovakia
Changhua Christian Hospital
🇨🇳Changhua, Taiwan
Mackay Memorial Hospital-Taipei branch
🇨🇳New Taipei City, Taiwan
Centro de Investigacion y Atencion de Diabetes, Endocrinologia y Nutricion
🇲🇽Durango, Mexico
Investigacion Biomedica Aplicada de Hidalgo S.A. de C.V.
🇲🇽Pachuca, Mexico
Fundacion Cardiovascular de Aguascalientes AC
🇲🇽Aguascalientes, Mexico
General Hospital Uzice
🇷🇸Uzice, Serbia
MEDI M&M s.r.o.
🇸🇰Moldava nad Bodvou, Slovakia
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Arechavaleta Granell Maria del Rosario
🇲🇽Guadalajara, Mexico
Hospital Universitario Dr. Jose Eleuterio González
🇲🇽Monterrey, Mexico
Diabetes Total, S.A de C.V.
🇲🇽Pachuca, Mexico
Centro de Alta Especialidad Dr. Rafael Lucio
🇲🇽Veracruz, Mexico
Clinical Hospital Center Bezanijska Kosa
🇷🇸Belgrade, Serbia
Clinical Hospital Centre Zemun
🇷🇸Belgrade, Serbia
Institute Niska Banja
🇷🇸Niska Banja, Serbia
Univerzitna nemocnica Bratislava
🇸🇰Bratislava, Slovakia
DIAB s.r.o.
🇸🇰Roznava, Slovakia
Chang Gung Medical Foundation Linkou Branch (Clinical Research Center)
🇨🇳Taoyuan City, Taiwan
Chi Mei Medical Center
🇨🇳Taipei, Taiwan
Centro de Desarrollo Biomédico
🇲🇽Merida, Mexico
Centro Para el Desarrollo de la Medicina y de Asistencia Especializada SC
🇲🇽Culiacan, Mexico
Dr. Humberto Alvarez Lopez
🇲🇽Zapopan, Mexico
Hospital Central Dr Ignacio Morones Prieto
🇲🇽San Luis Potosí, Mexico
Cardioarritmias e Investigación S.C.
🇲🇽San Luis Potosi, Mexico
Far Eastern Memorial Hospital
🇨🇳Taipei, Taiwan
INBIOMEDYC Toluca
🇲🇽Toluca, Mexico
Health Center Zajecar
🇷🇸Zajecar, Serbia
Clinical Center Kragujevac
🇷🇸Kragujevac, Serbia
Kaohsiung Chang Gung Memorial Hospital
🇨🇳Kaohsiung, Taiwan
Zentrum für Klinische Prüfung in der Facharztzentrum Dresden Neustadt Gbr
🇩🇪Dresden, Germany
Klinikum Leverkusen GmbH
🇩🇪Leverkusen, Germany
Research Cardiology Institute of Tomsk Scientific Center of RAMS Siberian Branch
🇷🇺Tomsk, Russian Federation
Multiprofile Hospital for Active Treatment - Prof. Dr. Paraskev Stoyanov AD
🇧🇬Lovech, Bulgaria
Synexus Affiliate - Diagnostic and Consulting Center Ascendent
🇧🇬Sofia, Bulgaria
Multiprofile Hospital for Active Treatment Sveta Marina EAD
🇧🇬Varna, Bulgaria
Hadassah University Hospital Ein Kerem
🇮🇱Jerusalem, Israel
Hillel Yaffe Medical Center
🇮🇱Hadera, Israel
Tel Aviv Sourasky Medical Center
🇮🇱Tel-Aviv, Israel
Baruch Padeh Poriya Medical Center
🇮🇱Tiberias, Israel
Centro Médico Libertad
🇦🇷Haedo, Argentina
Instituto de Cardiologia de Corrientes Juana Francisca Cabral
🇦🇷Corrientes, Argentina
CEMAIC
🇦🇷Córdoba, Argentina
Clínica Privada Del Prado Sociedad de Responsabilidad Limitada
🇦🇷Córdoba, Argentina
Fundación Clínica Colombo
🇦🇷Córdoba, Argentina
Instituto Del Corazón
🇦🇷Córdoba, Argentina
CIMEL
🇦🇷Lanús, Argentina
Instituto de Investigaciones Clínicas Mar Del Plata
🇦🇷Mar Del Plata, Argentina
DIM Clinica Privada
🇦🇷Ramos Mejia, Argentina
Hospital Central
🇦🇷Mendoza, Argentina
Instituto de Hematologia Y Medicina Clinica
🇦🇷Rosario, Argentina
Sanatorio Britanico de Rosario
🇦🇷Rosario, Argentina
Centro Modelo de Cardiologia
🇦🇷San Miguel De Tucumán, Argentina
Investigaciones Clinicas Tucuman
🇦🇷San Miguel De Tucumán, Argentina
Grupo Medico Alem
🇦🇷San Isidro, Argentina
Bioclinica Tucumán
🇦🇷San Miguel De Tucumán, Argentina
Centro de Investigaciones Clínicas Del Litoral SRL
🇦🇷Santa Fe, Argentina
Sanatorio San Francisco
🇦🇷Santiago Del Estero, Argentina
Instituto de Investigaciones Clínicas Zárate
🇦🇷Zárate, Argentina
Bajai Szent Rókus Kórház
🇭🇺Baja, Hungary
Semmelweis Egyetem
🇭🇺Budapest, Hungary
Selye János Kórház
🇭🇺Komárom, Hungary
Bajcsy-Zsilinszky Korhaz es Rendelointezet
🇭🇺Budapest, Hungary
Gottsegen Gyorgy Orszagos Kardiologiai Intezet
🇭🇺Budapest, Hungary
Magyar Honvédség Egészségügyi Központ
🇭🇺Budapest, Hungary
Synexus (DRS) - Synexus Magyarország Kft. Budapest
🇭🇺Budapest, Hungary
Tolna Megyei Balassa János Kórház
🇭🇺Szekszárd, Hungary
Instituto Médico DAMIC
🇦🇷Córdoba, Argentina
Szent Margit Korhaz
🇭🇺Budapest, Hungary
Nazareth EMMS Hospital
🇮🇱Nazareth, Israel
Clínica FUSAVIM Privada
🇦🇷Villa María, Argentina
Ipac Caraffa
🇦🇷Córdoba, Argentina
Prevencion Cardio Vascular
🇦🇷Salta, Argentina
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont
🇭🇺Szeged, Hungary
Barzilai Medical Center
🇮🇱Ashkelon, Israel
Lady Davis Carmel Medical Center
🇮🇱Haifa, Israel
University Multiprofile Hospital for Active Treatment - Dr. Georgi Stranski EAD
🇧🇬Pleven, Bulgaria
University Multiprofile Hospital for Active Treatment and Emergency Medicine N. I. Pirogov EAD
🇧🇬Sofia, Bulgaria
Grof Tisza Istvan Korhaz Berettyoujfalu
🇭🇺Berettyóújfalu, Hungary
Szent Rókus Kórház és Intézményei
🇭🇺Budapest, Hungary
Coromed-SMO Kft.
🇭🇺Pécs, Hungary
Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
🇭🇺Székesfehérvár, Hungary
Rambam Medical Center
🇮🇱Haifa, Israel
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Centro de Investigacion Medica Biologica Y de Terapia Avanzada SC
🇲🇽Guadalajara, Mexico
Hospital Angeles Leon
🇲🇽León De Los Aldama, Mexico
Sanatorio y Servicios Médicos Obregón S.A. de C.V.
🇲🇽Mexico City, Mexico
IMED Internal Medicine Clin Trials
🇲🇽Monterrey, Mexico
Gabinet Kardiologiczno-Internistyczny
🇵🇱Gdynia, Poland
OLVG locatie Oost
🇳🇱Amsterdam, Netherlands
Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej Centralny Szpital Weteranow
🇵🇱Lódz, Poland
Medicome Sp. z o.o.
🇵🇱Oswiecim, Poland
Prywatna Praktyka Lekarska MAZ-MEDICA Maciej R.Mazurkiewicz
🇵🇱Lodz, Poland
Niepubliczny Zaklad Opieki Zdrowotnej Centrum Medyczne SBB
🇵🇱Tarnobrzeg, Poland
Centrum Kardiologiczne Pro Corde Sp. z o.o. Niepubliczny Zaklad Opieki Zdrowotnej
🇵🇱Wroclaw, Poland
Instytut Kardiologii im Prymasa Tysiaclecia Kardynala Stefana Wyszynskiego
🇵🇱Warszawa, Poland
Wro Medica
🇵🇱Wroclaw, Poland
City Clinical Hospital #6
🇷🇺Chelyabinsk, Russian Federation
Ural State Medical University
🇷🇺Ekaterinburg, Russian Federation
Federal Budget Healthcare Institution Medici - sanitary unit of Ministry of internal affairs of Russ
🇷🇺Kemerovo, Russian Federation
Research Institute of Complex Cardiovascular Pathology
🇷🇺Kemerovo, Russian Federation
Krasnodar Regional Clinical Hospital #2
🇷🇺Krasnodar, Russian Federation
Moscow City State Budgetary Healthcare Institution City Clinical Hospital named after V.V. Veresayev
🇷🇺Moscow, Russian Federation
Russian Cardiology Research and Production Center
🇷🇺Moscow, Russian Federation
Republican Hospital n.a. V.A. Baranov
🇷🇺Petrozavodsk, Russian Federation
Municipal Budgetary Healthcare Institution City Emergency Hospital
🇷🇺Rostov-on-Don, Russian Federation
State Budgetary Healthcare Institution of Novosibirsk Region City Clinical Hospital No. 19
🇷🇺Novosibirsk, Russian Federation
International Medical Center SOGAZ
🇷🇺Saint Petersburg, Russian Federation
Saratov State Medical University
🇷🇺Saratov, Russian Federation
North-West State Medical University n.a. I.I. Mechnikov
🇷🇺Saint Petersburg, Russian Federation
State Healthcare Institution Regional Clinical Cardiologic Dispensary
🇷🇺Saratov, Russian Federation
City Hospital #4
🇷🇺Sochi, Russian Federation
Clinical Center of Serbia
🇷🇸Belgrade, Serbia
State Budgetary Healthcare Institution of Vladimir Region City Hospital No. 4
🇷🇺Vladimir, Russian Federation
Clinical Hospital Centar Zvezdara
🇷🇸Belgrade, Serbia
Euromedik
🇷🇸Belgrade, Serbia
Institute of Cardiovascular Diseases Dedinje
🇷🇸Belgrade, Serbia
Military Medical Academy
🇷🇸Belgrade, Serbia
KBC Dr Dragisa Misovic Dedinje
🇷🇸Belgrade, Serbia
Clinical Center Nis
🇷🇸Nis, Serbia
Institute of Cardiovascular Diseases of Vojvodina
🇷🇸Sremska Kamenica, Serbia
ALIAN, s.r.o
🇸🇰Bardejov, Slovakia
CARDIOCONSULT, s.r.o.
🇸🇰Bratislava, Slovakia
Kardio-Onkologia, s.r.o.
🇸🇰Dolny Kubin, Slovakia
CARDIO D&R, s.r.o. Kosice
🇸🇰Kosice, Slovakia
Zeleznicne zdravotnictvo Kosice, s.r.o.
🇸🇰Kosice, Slovakia
Nemocnica s poliklinikou Nove Mesto nad Vahom n.o.
🇸🇰Nove Mesto nad Vahom, Slovakia
MEDIVASA, s.r.o.
🇸🇰Zilina, Slovakia
Kaohsiung Veterans General Hospital
🇨🇳Kaohsiung, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan City, Taiwan
Tri-Service General Hospital
🇨🇳Taipei City, Taiwan
Cathay General Hospital
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
General Hospital Dr Josip Bencevic
🇭🇷Slavonski Brod, Croatia
Niepubliczny Zaklad Opieki Zdrowotnej AURUM
🇵🇱Warszawa, Poland