PRactice of VENTilation in Critically Ill PEDiatric Patients (PRoVENT-PED) - an International Multicenter Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 2,500
- 试验地点
- 1
- 主要终点
- Peak inspiratory pressure
研究概览
简要总结
The goal of this worldwide observational study is to investigate ventilation practice in critically ill pediatric patients. The main questions it aims to answer are:
- What is the global current practice of ventilatory support in critically ill pediatric patients?
- Which potentially modifiable factors related to ventilation are associated with outcome? Participating pediatric intensive care units will gather detailed information about ventilation practice and outcome, such as duration of ventilatory support, length of ICU stay and ICU mortality.
详细描述
Rationale:
Studies on ventilatory support in critically ill pediatric patients remain scarce and much of the current clinical practice is based upon experience and data originating from critically ill adult patients.
Objectives:
- To describe the worldwide practice of ventilatory support in critically ill pediatric patients; and
- To identify potentially modifiable ventilation parameters that have independent associations with outcome.
Hypothesis:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Expected use of (non-)invasive respiratory support for at least 12 hrs
排除标准
- •premature infants (i.e., postconceptional age corrected for gestational age < 40 weeks)
结局指标
主要结局
Peak inspiratory pressure
时间窗: First four days of (non-)invasive respiratory support
Peak inspiratory pressure
Plateau pressure
时间窗: First four days of (non-)invasive respiratory support
Pateau pressure
Driving pressure
时间窗: First four days of (non-)invasive respiratory support
Driving pressure
Mechanical power
时间窗: First four days of (non-)invasive respiratory support
Mechanical power
Positive end-expiratory pressure
时间窗: First four days of (non-)invasive respiratory support
Positive end-expiratory pressure
Tidal volume
时间窗: First four days of (non-)invasive respiratory support
Tidal volume
次要结局
- Duration of respiratory support (in days)(Up to 28 days following initiation of (non-)invasive respiratory support)
- ICU mortality(Up to 28 days following initiation of (non-)invasive respiratory support)
- Ventilator-free days at day 28(Up to 28 days following initiation of (non-)invasive respiratory support)
- Length of ICU stay (in days)(PICU admission)
- PARDS prevalence(First four days of (non-)invasive respiratory support)