Assessment and Mechanistic Investigation of Cognitive Impairment Following Hemorrhagic Stroke

Phase 1

• Conditions: Hemorrhagic Stroke, Subarachnoid Hemorrhage

• Registration Number: ChiCTR2400088795
• Lead Sponsor: West China Hospital, Sichuan University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

According to the Chinese Guidelines for the Diagnosis and Treatment of Aneurysmal Subarachnoid Hemorrhage, published by the Stroke Prevention and Control Engineering Committee of the National Health and Family Planning Commission in 2016, a head CT scan indicating subarachnoid hemorrhage, along with confirmation of an intracranial aneurysm using CT angiography (CTA), digital subtraction angiography (DSA), or magnetic resonance angiography (MRA), is required.The diagnosis of spontaneous intracerebral hemorrhage is based on the Chinese Guidelines for the Clinical Management of Cerebrovascular Diseases 2023 and the American Heart Association/American Stroke Association Guidelines for the Management of Spontaneous Intracerebral Hemorrhage 2022. It requires CT confirmation of a hemorrhagic lesion in the brain parenchyma, while ruling out secondary causes such as trauma and vascular diseases, as described below.

Exclusion Criteria

1. Exclude traumatic subarachnoid hemorrhage, hematologic diseases, coagulation disorders, hypertensive cerebral hemorrhage with intraventricular extension, arteriovenous malformations (AVM) and other intracranial vascular malformations, moyamoya disease, intracranial tumor stroke, pseudoaneurysms, etc.<br>2) Exclude congenital hydrocephalus and hydrocephalus that existed prior to subarachnoid hemorrhage.<br>3) Exclude pregnant patients.<br>4) Exclude patients with age less than 18 years

Study & Design

• Study Type: Observational study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
mRS score at 6 months;

Secondary Outcome Measures

Name	Time	Method
In-hospital mortality;mRS score at 3 months;MoCA score at 3 months;MoCA score at 6 months;