Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis

Not Applicable

Recruiting

• Conditions: Platelets-rich Plasma; Osteoarthritis Knees Both; Meniscus Disorder; Cartilage Injury
• Interventions: Drug: Sodium hyaluronate injection

• Registration Number: NCT06082531
• Lead Sponsor: Xijing Hospital

Brief Summary

To evaluate the safety and effectiveness of PRP injection therapy in the repair of osteoarthritis and periarticular soft tissue injury through a single-center, exploratory clinical study, and to provide a more reliable basis for the treatment of joint injury.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-09-01
• Study First Submitted: 2023-10-09
• Study First Submitted QC: 2023-10-09
• Study First Posted: 2023-10-13
• Status Verified: 2024-09
• Last Update Submitted: 2025-04-06
• Last Update Posted: 2025-04-09
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• The age range of the participants was 20 to 60 years old. Through a comprehensive clinical and imaging examination, it was conclusively determined that the individuals had knee osteoarthritis or experienced injuries to the cart, and meniscus surrounding the knee joint.
• The preoperative routine tests and examinations revealed no contraindications.
• Revised sentence: "Informed consent of the patient

Exclusion Criteria

• The platelet count or function exhibits significant abnormalities、Systemic infection transmitted through the bloodstream.
• Prolonged usage of anti-inflammatory drugs and systemic corticoid administration.
• In injection site or damage to the skin.
• Patients with tumors or undergoing radiotherapy and chemotherapy.
• Pregnant or breastfeeding women.
• Individuals with mental illnesses who are unable to cooperate with follow-up procedures.
• Contraindications for MRI、Patients or their families do consent to participate in the study.
• Other circumstances that render participation in the study unsuitable.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
postoperative (6 weeks)	Sodium hyaluronate injection	The patients were injected with PRP.
postoperative (3 months)	Sodium hyaluronate injection	The patients were injected with PRP.

Primary Outcome Measures

Name	Time	Method
MRI	pre-operation,3 weeks after treatment, 6 months after treatment	The injury of ligaments, meniscus, and the knee joint was assessed using MRI.
X-ray	pre-operation,3 weeks after treatment, 6 months after treatment	The postoperative plain X-ray film was utilized for the assessment of knee joint deformity, stenosis of the joint space, and hyperplasia of osteophytes.
CT	pre-operation,3 weeks after treatment, 6 months after treatment	The application of three-dimensional CT scan for the assessment of articular cartilage defects.

Trial Locations

Locations (1)

Xijing Hospital; 🇨🇳 Xi'an, Shannxi, China