Phase I/II trial of chemoradiotherapy concurrent with S-1 and cisplatin in patients with clinical stage II/III esophageal carcinoma (JCOG0604) - JCOG0604

Japan Clinical Oncology Group(JCOG)0 个研究点目标入组 81 人开始时间: 2007年5月11日最近更新: 2023年10月17日

试验速览

暂无简介。

•1) Histologically proven squamous cell carcinoma or adenocarcinoma or adenosquamous cell carcinoma of the esophagus
•2) Primary lesion are located within the thoracic esophagus (Te)
•3) Clinical stage II or III without T4
•4) Aged 20 to 70 years old
•5) ECOG PS of 0 or 1
•6) no need for measurable lesion
•7) no previous treatment of esophageal cancer
•8) no previous chemotherapy or radiotherapy against any other malignancies
•9) adequate water intake
•10) no palsy of recurrent nerve
•11) adequate organ functions
•12) refused esophagectomy
•13) written informed consent

•1) Simultaneous or metachronous (within 5 years) double cancers , with the exception of intramucosal tumor curable with local therapy
•2) Patients requiring the administration of phenytoin or warfarin potassium
•3) Pregnant or lactating women or women of childbearing potential
•4) Psychosis
•5) Patients requiring systemic steroids medication
•6) HBs antigen positive
•7) Uncontrollable diabetes millutus or requiring administration of insulin
•8) Uncontrollable hypertension
•9) History of myocardial infarction or unstable angina pectoris
•10) Interstitial pneumonia, fibroid lung or severe emphysema
•11) Active bacterial or fungous infection

发起方

Japan Clinical Oncology Group(JCOG)