The effects of oral administration of lactobacillus plantarum WCFS1, Lactobacillus plantarum CIP104448, and Lactobacillus plantarum CIP104450 on small intestinal mucosa and barrier functio

Completed

• Conditions: gastrointestinal discomfort; irritable bowel syndrome; 10017969

• Registration Number: NL-OMON35954
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

no gastrointestinal complaints
age between 18 and 65 yrs
BMI between 20 and 30 kg/m2

Exclusion Criteria

medication, except oral contraceptives
major abdominal surgery interfering with gastrointestinal function in the 180 days prior to study
smoking

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Effects on immune modulation. Measurement of IL-10 and IL-12 production<br /><br>2. Effect on intestinal epithelial permeability.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. Effects on epithelial gene regulation, tight junction modulation<br /><br>2. Effects on peripheral markers of immune regulation, immune parameters</p><br>