My spine is on fire: neuroinflammation in cervical radiculopathy and physiotherapy

VU University Amsterdam0 个研究点目标入组 24 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•Cervical radiculopathy
•Age between 30-65 years.
•Minimal score of 4 on the Numeric Pain Rating Scale (0-10).
•Cervical radiculopathy based on the clinical diagnosis confirmed by the Magnetic Resonance Imaging (MRI
•through a medical specialist). The compression must be caused by a discus protrusion or herniation.
•Written informed consent of the subject.
•Referral by a medical specialist
•High and mixed affinity binders for second generation TSPO radiotracers
•Healthy control group
•Age between 30-65 years.
•Asymptomatic for neck or shoulder pain and other musculoskeletal conditions in the past 3 months.
•Written informed consent of the subject.
•Referral by a medical specialist
•High and mixed affinity binders for second generation TSPO radiotracers

•Cervical radiculopathy and healthy control group
•A potential subject who meets any of the following criteria will be excluded from participation in this study:
•Pregnancy or postpartum for 9 months
•Contra-indications for venipuncture (e.g. phlebitis)
•Underwent treatment for current complaints for the last 2 weeks (e.g. physiotherapy, manual therapy, general
•practitioner etc.)
•Taken one of the following medications for the last 6 weeks: corticosteroids (e.g. prednisone), immunomodulatory
•medication (e.g. methotrexate, infliximab etc.) and the use of botox for the last 3 months.
•Taken one of the following medication: NSAID’s (e.g. diclofenac, ibuprofen, naproxen etc.), Aspirin, Simvastatin
•(29) for the last week.
•Benzodiazepine (30) use for the last six weeks.
•MRI contraindications, (e.g. claustrophobia, inability to lie still in the scanner or metal objects in or around the
•Inability to undergo PET-CT with administration of radioligand [¹¹C]-R-DP713.
•Significant radiation exposure such that inclusion in this study will take the total dose >10mSv within the
•preceding 12 months.
•Current participation in another clinical trial.
•Previous participation in a PET-CT study in the last 12 months.
•Having a medical disease with immune system involvement (e.g. MS, Spondylitis Ankylpoetica)

发起方

VU University Amsterdam