ovel approaches to manage glucocorticoid-induced diabetes in hospital inpatients

Phase 4

• Conditions: glucocorticoid-induced or -exacerbated diabetes; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12615000333516
• Lead Sponsor: Alfred Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-04-13
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Glucocorticoid-induced or exacerbated diabetes treated with insulin and/or oral glucose-lowering medication(s)
Glucose >= 15 mmol/l

Exclusion Criteria

Type 1 diabetes
Admission to intensive care
Likely to require surgical intervention
Likely to be admitted <48 h
eGFR <15 ml/min
Acute vomiting or history of gastroparesis
Known allergy to insulin or GLP-1 agonists
Proliferative retinopathy
Premenopausal females

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time spent with normoglycaemia as determined by continuous glucose monitoring[72 h]

Secondary Outcome Measures

Name	Time	Method
mean glucose as determined by continuous glucose monitoring[72 h];total daily insulin obtained from drug chart[72 h];peak glucose as determined by continuous glucose monitoring[72 h];glycemic variability as determined by continuous glucose monitoring[72 h];Hypoglycaemia (BGL < 3.5 mmol/L and/or clinical evidence of hypoglycaemia) as determined by continuous glucose monitoring[72 h];Hyperglycaemia (BGL>18 mmol/L) as determined by continuous glucose monitoring[72 h]