The Relationship Between Preoperative Frailty and Postoperative Acute Kidney Injury in Patients Undergoing Non-cardiac Surgery and the Mediating Effect of Intraoperative Blood Pressure: A Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 515
- 试验地点
- 1
- 主要终点
- Postoperative acute kidney injury
研究概览
简要总结
The primary objectives of study is to compare the difference in the incidence of postoperative AKI between frail and non-frail patients. The secondary objectives of study was to compare the differences in intraoperative blood pressure fluctuations, the incidence and duration of intraoperative hypotension, postoperative complications, length of hospital stay and hospitalization expenses between frail and non-frail patients, and use mediating effect analysis to examine the magnitude of the effect of intraoperative blood pressure on postoperative acute kidney injury caused by frailty.
详细描述
This study is a single-center prospective cohort study. It is expected to include patients who meet the inclusion and exclusion criteria from July 2025 to February 2026. The demographic characteristics, laboratory indicators, preoperative comorbidities of the patients will be recorded and frailty assessment will be conducted within one week before the operation. The patients were divided into the frail group and the non-frail group. Record the surgery-related information of the patient on the day of the operation. During the operation, vital signs such as the patient's blood pressure and heart rate were routinely detected. The anesthesiologist adopted an experience-guided anesthesia management approach, and the doctor in charge of anesthesia management was also unaware of the patient's frailty status. Record the indicators such as the dosage of anesthetic drugs during the operation, the duration of surgical anesthesia, the use of vasoactive drugs and the fluid intake and output of the patients. The incidence of AKI, the incidence of in-hospital complications, the length of hospital stay and the hospitalization costs of the patients were recorded after the operation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years old or above
- •Undergo non-cardiac surgery
排除标准
- •At least one measurement of serum creatinine (SCr) was not conducted before and after the operation
- •End-stage renal disease (ESRD) that has received dialysis within the past year
- •Baseline SCr ≥ 4.5 mg/dl (because the clinical criteria for AKI based on elevated SCr may not be applicable to these patients)
- •Acute kidney injury occurred within 7 days before the operation
- •No frailty assessment was conducted
- •The operation time is less than 2 hours
结局指标
主要结局
Postoperative acute kidney injury
时间窗: Within one week after the operation
次要结局
- Intraoperative blood pressure(During the operation)
- Postoperative complications(Perioperative period)
- Hospital stays(Perioperative period)
- Hospitalization costs(Perioperative period)
研究者
Lanyue Zhu
Attending Doctor
Zhongda Hospital