The effectiveness of Spirulina platensis algae and N-acetyl cysteine for treatment of patients with COVID-19 infectio

Phase 1

Recruiting

Conditions: Patients with COVID-19 infection.
COVID-19, virus identified
U07.1

Registration Number: IRCT20220509054793N1

Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 60

Inclusion Criteria

Patients with COVID-19 infection base on clinical manifestations, chest CT scan and PCR test results
Age over 18 years
The oxygen saturation of patient is 85 percent or greater at rest

Exclusion Criteria

having chronic lung disease
Pregnant women
Having autoimmune disease
History of allergy to the seaweed or its derivatives
History of bronchospasm after using of N-acetylcysteine
Having chronic liver disease
History of phenylketonuria
Having bleeding (Massive hemoptysis, gastrointestinal bleeding, epistaxis, purpura, ecchymosis)
Neutrophil count of less than 500 mmc
A platelet count of less than 2000 mmc
Having acute hepatitis

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The duration of hospitalization. Timepoint: Two weeks after intervention. Method of measurement: The number days of hospitalization.;Improvement rate of clinical symptoms such as dyspnea and fever. Timepoint: Three months weeks after intervention. Method of measurement: Based on clinical examinations.;Possibility of hospitalization in ICU. Timepoint: Two weeks after intervention. Method of measurement: Need to receive intensive care in the patient.;Mortality rate. Timepoint: One month after intervention. Method of measurement: Calculating a mortality rate.

Secondary Outcome Measures

Name	Time	Method
Acute respiratory distress syndrome rate. Timepoint: Two weeks after intervention. Method of measurement: Patient with acute respiratory distress syndrome.