To test the use of a Microdialysate Automated Collection Device for cortisol sampling and to assure reproducibility in the LUMC of data reported by others
Recruiting
- Conditions
- onderzoek heeft in eerste instantie betrekking op normale fysiologische situatie, in tweede instantie patienten met bijnierinsufficientieadrenal insufficiencyhealthy peoplephysiological situation10001353
- Registration Number
- NL-OMON47911
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
First: Healthy adult males or females, aged between 20-60 years
Only if insufficient data, also adults with adrenal insufficiency, males or females, aged between 20-60 years
Exclusion Criteria
Pregnancy, Allergy to local anaesthetic, hydrocortisone replacement therapy or any known abnormalities to the HPA axis (the latter only in case of healthy persons, first step of the protocol).
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- Peripheral tissue cortisol profiles/day rhythms<br /><br>- Reproducibility results reported by other groups</p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>