Does Intravenous Cannabis Reduce Postoperative Nausea and Vomiting (PONV)?
- Registration Number
- NCT00695487
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Brief Summary
The investigators evaluate if intravenously applied THC (Cannabis) reduces postoperative Nausea and vomiting. THC will be given during anesthesia before emergence. We measure how long and how effective it reduces PONV
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 320
Inclusion Criteria
- ASA I-III
- elective open and laparoscopic surgery >1hour
Exclusion Criteria
- ambulatory surgery
- pregnancy, breast feeding
- >ASA III
- BMI >35
- antipsychotic, antiemetic, cytostatic therapy
- major cardiovascular, renal, hepatic, central nervous system disease
- current chronic cannabis consumption and hard drug abuse
- schizophrenia
- preoperative nausea and vomiting, vestibular disease
- not speaking german or french
- refusal to participate
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 THC 9-d-tetra hydro cannabinol Receives 0.125mg/kg THC before emergence 2 THC 9-d-tetra hydro cannabinol Receives NaCl before emergence
- Primary Outcome Measures
Name Time Method Absence of postoperative Nausea and Vomiting 0-24h after Operation
- Secondary Outcome Measures
Name Time Method Psychological and physiological data after ingestion of THC Analgetics required 0-24h after operation
Trial Locations
- Locations (1)
Inselspital, Bern University Hospital
🇨ðŸ‡Bern, Switzerland