NCT00695487终止不适用
Does Intravenous Cannabis Reduce Postoperative Nausea and Vomiting (PONV)?
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 320
- 试验地点
- 1
- 主要终点
- Absence of postoperative Nausea and Vomiting
研究概览
简要总结
The investigators evaluate if intravenously applied THC (Cannabis) reduces postoperative Nausea and vomiting. THC will be given during anesthesia before emergence. We measure how long and how effective it reduces PONV
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA I-III
- •elective open and laparoscopic surgery >1hour
排除标准
- •ambulatory surgery
- •pregnancy, breast feeding
- •>ASA III
- •antipsychotic, antiemetic, cytostatic therapy
- •major cardiovascular, renal, hepatic, central nervous system disease
- •current chronic cannabis consumption and hard drug abuse
- •schizophrenia
- •preoperative nausea and vomiting, vestibular disease
- •not speaking german or french
- •refusal to participate
研究组 & 干预措施
1
Experimental
Receives 0.125mg/kg THC before emergence
干预措施: THC 9-d-tetra hydro cannabinol (Drug)
2
Placebo Comparator
Receives NaCl before emergence
干预措施: THC 9-d-tetra hydro cannabinol (Drug)
结局指标
主要结局
Absence of postoperative Nausea and Vomiting
时间窗: 0-24h after Operation
次要结局
- Psychological and physiological data after ingestion of THC Analgetics required(0-24h after operation)
研究者
研究点 (1)
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