Comparison of Sedation and General Anesthesia With Laryngeal Mask in Therapeutic Bronchoscopy
Overview
- Phase
- Not Applicable
- Intervention
- Dexmedetomidine
- Conditions
- Bronchoscopy
- Sponsor
- Changhai Hospital
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Recovery time
- Status
- Terminated
- Last Updated
- 6 years ago
Overview
Brief Summary
Therapeutic bronchoscopy is a common procedure to treat respiratory diseases. The procedure includes stent implantation, bronchus dilation, electronic incision, laser therapy, and so on. Most of these procedures are painful and require general anesthesia. Conventionally, the general anesthesia for therapeutic bronchoscopy was performed using laryngeal mask. But in the previous experiences, the investigators found that sedation with dexmedetomidine and remifentanil was as effect as laryngeal mask anesthesia. The present study was performed to compare the two approach for sedation or anesthesia in therapeutic bronchoscopy.
Investigators
Jia-feng Wang
MD
Changhai Hospital
Eligibility Criteria
Inclusion Criteria
- •Scheduled for flexible therapeutic bronchoscopy
- •Adult patients aged 18 to 65 years
- •American Society of Anesthesiologists (ASA) Physical Status Classification I-II
- •BMI 18.5-25kg/m2
- •Subjects provide informed consent
Exclusion Criteria
- •Severe airway obstruction
- •Coagulation disorder
- •Repeat bronchoscopy (more than 3 times)
- •Severe liver and renal dysfunction
- •Cardiovascular and cerebrovascular diseases
- •Pregnancy
- •Chronic opioid user
- •Drug abusers or addicts
Arms & Interventions
Group DR
Patients sedated with dexmedetomidine and remifentanil.
Intervention: Dexmedetomidine
Group DR
Patients sedated with dexmedetomidine and remifentanil.
Intervention: Remifentanil
Group LMA
General anesthesia was applied using laryngeal mask.
Intervention: Laryngeal mask
Outcomes
Primary Outcomes
Recovery time
Time Frame: After termination of the sedation medication, assessed up to 3 hours
Duration of the recovery from sedation
Secondary Outcomes
- Cost of anesthesia or sedation(Across the sedation or anesthesia, assessed up to 3 hours)
- Cough score(From the completion of local anesthesia with lidocaine to the completion of bronchoscopy procedure, assessed up to 3 hours)
- The numbers of the times of body movement(From the completion of local anesthesia with lidocaine to the completion of bronchoscopy procedure, assessed up to 3 hours)
- Satisfaction score of the patients and bronchoscopists(Across the procedure, assessed up to 3 hours)
- Prevalence of the side effects of respiratory and circulatory system(Across the sedation or anesthesia, assessed up to 3 hours)