Duration of peripheral nerve blocks in opioid tolerant individuals- A volunteer blinded matched case-control study

Region Midtjylland0 个研究点目标入组 40 人开始时间: 2023年12月1日最近更新: 2024年7月22日

适应症

试验速览

暂无简介。

•Age > 18 years old, ASA 1-3, Legally competent and able to give informed consent, Chronic pain, defined as persisting pain for more than three months (opioid group), The daily use of 60 mg or more of morphine equivalent for more than a month (opioid group)

•Volunteers who cannot cooperate with the study, Pathology or previous major surgery to the upper limb, Active signs of infection in the cutaneous area of injection, Pregnancy at the time of the trial, Volunteers diagnosed with partial or complete 2nd or 3rd degree atrioventricular heart block without a pacemaker, Age > 84 years, Volunteers diagnosed with severe liver disease, Volunteers diagnosed with severe kidney disease and reduced kidney function (eGFR below 30 mL/min), Volunteers in daily treatment with drugs that are structurally related to local analgesics or class IB antiarrhythmics, as the toxic effects are additive, Volunteers in daily treatment with class III antiarrhythmics e.g., amiodarone., Volunteers who cannot understand or speak Danish, Volunteers with allergy to the lidocaine or the preservatives used in the study, Volunteers suffering from alcohol or drug abuse other than opioids, Peripheral neuropathy at the upper limb non-dominant arm

发起方

Region Midtjylland