Determination and/or following of High on-aspirin platelet reactivity (HARP) in CABG patients using the Verifynow Aspirin.

Completed

• Conditions: Aspirin resitance; High on-aspirin platelet reactivity; 10011082

• Registration Number: NL-OMON37275
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2014-06-09
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 21

Inclusion Criteria

Elective pre-CABG patients (with during the CABG use of Heartlung machine)
Use of preoperative Aspirin

Exclusion Criteria

Use of other platelets aggregation inhibiting medicines, NSAID'S, GPIIb/IIIa receptor antagonists, anticoagulants and/or heparines. (e.g., Dipyridamole, Acenocoumarol, Nadroparine, Plavix, etc.)
Under-age patients and minors.
Insufficient mastery of the Dutch or English to get wel informed.
Intolerance to aspirin.
Coagulation abnormalities, congenital platelets abnormalities and/or medication (non-aspirin) induced platelet abnormality

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoint is the moment that the number of 20 study subjects is<br /><br>reached and there have been five measurements of ARU with each patient.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-Average of ARU's per moment of measurement.<br /><br>-Difference in the ARU's per individual at different measuring moments.<br /><br>-The time of first postoperatively Aspirin gift.<br /><br>-Number of platelets at each measurement moment.<br /><br>-Number and amount of any per-and postoperative platelet transfusions.<br /><br>-Possible post-operative interventions (such as PCI, re-CABG, etc.) until the<br /><br>measuring time T5.</p><br>