Brain Health and Root Causes of Stroke Risk Disparity in Wisconsin Native Americans
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Number of strokes
研究概览
简要总结
The purpose of this observational study is to better understand the relationship between stroke risk factors and brain MRI measures in the Native American population.
Participants will undergo:
- Carotid ultrasound
- Magnetic resonance imaging (MRI)
- Cognitive testing
详细描述
Researchers' central hypothesis is that Native Americans (NAs) suffer from chronic psychological stress (PS) and inter-generational trauma related to historical loss (HL) which are manifested as inflammatory proteomic changes, leading to atherosclerotic vessel wall injury, stroke and vascular cognitive impairment (VCI). The researchers present a study to determine if MRI brain health metrics such as structural and functional connections, cerebral blood flow measures, brain morphometry are correlated with cardiovascular risk factors, atherosclerotic disease burden, blood inflammatory proteins, and scores on the Oneida cultural nutritional programs.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 55 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 55-90
- •Receiving healthcare though the Oneida Comprehensive Health Division
排除标准
- •Not Native American
- •Contraindications to MRI scans
结局指标
主要结局
Number of strokes
时间窗: 3 months
Imaging helps assess number of strokes, understanding the type of stroke, underlying causes for stroke, identification of vascular malformations, treatment planning and outcomes prediction.
Cortical thickness
时间窗: 3 months
Cortical thickness is measured using T1w MRI imaging. Normal thickness is 1-4.55mm - average is about 2.5mm, below that range is considered thinning.
White matter lesion buildup
时间窗: 3 months
Buildup is measured using T2-FLAIR White Matter Hyperintensities (WMHs). Number and extent of WMHs is normalized based on head size.
Microstructural integrity
时间窗: 3 months
DTI (Diffusion Tensor Imaging) visualizes the structure of the brain's white matter. It helps understand how brain regions are connected.
Cerebral blood flow
时间窗: 3 months
Cerebral blood flow is measured using ASL perfusion MRI imaging. This technique provides quantitative measure of blood flow to brain tissue, which allows to assess brain function.
Atherosclerotic vascular buildup
时间窗: 3 months
Atherosclerotic vascular buildup is measured using 4Dflow MRA imaging. This technique allows for a more detailed visualization and quantification of blood flow patterns.
次要结局
- Brain connectivity(3 months)