Impact of Cataract Surgery on Keratoplasty Graft Survival
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 453
- 试验地点
- 1
- 主要终点
- Corneal transplant graft survival
研究概览
简要总结
The follow up time after keratoplasty now routinely exceeds multiple decades. It is common for keratoplasty patients to also undergo cataract surgery at a later date in their lives.
Keratoplasties and cataract surgery both result in local inflammation. This may influence the density of endothelial cells, and on average there is a loss of 10% in endothelial cells within 3 months of the cataract surgery. Yet, a sufficient density of endothelial cells is required to maintain graft transparency. It may be therefore difficult to strike a balance between loss of visual acuity due to the cataract of to the loss of graft transparency over the long term.
The investigators aim to compare graft survival in patients with clear crystalline lens with and without cataract surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients undergoing keratoplasty
- •Between january 1983 and december 2012
- •Age 40 and older at the time of surgery
排除标准
- •Cataract surgery prior to the keratoplasty
- •Systemic inflammatory disease
- •Previous history of uveitis
结局指标
主要结局
Corneal transplant graft survival
时间窗: 10 years
次要结局
- Corneal endothelial cell density(10 years)