ACTRN12622000610730
Recruiting
未知
Evaluating the feasibility and acceptability of a combined treatment for depression using a personalised psychosocial intervention and Vortioxetine in older adults.
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Depression
- Sponsor
- Royal Melbourne Hospital
- Enrollment
- 40
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Capacity to provide informed consent.
- •Aged between 50 – 75 years of age.
- •Able to see and hear, with or without sensory aids (e.g. glasses or hearing aids).
- •Has adequate English skills to participate.
- •Able to read and write.
- •Has a Medicare card and a regular General Practitioner.
- •Consents to the study team contacting their General Practitioner.
- •Consent to take Vortioxetine during the study.
- •Participants must not currently be taking anti\-depressant medication.
- •Current moderate depressive symptoms as confirmed by the Mini International Neuropsychiatric Interview (MINI).
Exclusion Criteria
- •Living in residential aged care (e.g. hostel or nursing home).
- •Current alcohol and/or substance use disorder (DSM\-5\).
- •Presence of a co\-morbid psychiatric disorder other than mild to moderate depression that is a focus of clinical concern as confirmed by the MINI (e.g. schizophrenia or bipolar disorder).
- •Depression symptom severity demonstrated as severe (36\-60\) according the Montgomery Asberg Depression Rating Scale (MADRS).
- •People currently on antidepressant medication (except for Vortioxetine).
- •People who are pregnant, trying to get pregnant or breast\-feeding.
- •People with active suicidality or a history of suicide attempt(s) within the past 2 years.
- •Brain injury, neurological condition or impairment which could affect cognitive function (e.g. neurodevelopmental disorders, neurodegenerative disease, dementia).
- •People currently taking medications approved for and/or employed off\-label for cognitive dysfunction (e.g. psychostimulants).
- •People currently taking any medication for a general medical disorder that in the opinion of the investigator may affect cognitive function (e.g. corticosteroids, beta\-blockers).
Outcomes
Primary Outcomes
Not specified
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