Perioperative Endothelial Dysfunction in Patients Undergoing Minor Abdominal Surgery. The POETRY Minor Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change in endothelial function assessed by the EndoPat system
研究概览
简要总结
This study on minor surgery serves to explore whether a dose-response relationship exists between surgical stress and endothelial dysfunction in the early postoperative period. The aim of this explorative and observational clinical study is to closely examine the endothelial function and its dynamics in the early postoperative period after minor surgery (lap. inguinal hernia repair). The endothelial function will be assessed indirectly by EndoPat and plasma biomarkers of nitric oxide bioavailability. The study will contribute to the understanding of perioperative myocardial injury, which is crucial for optimized treatment of patients at risk of cardiovascular complications.
详细描述
The investigators will include 60 patients undergoing elective inguinal hernia repair. The endothelial function will be measured before surgery and 4 hours after surgery with the EndoPat system. The NO-bioavailibility will be measured by plasma l-arginine, plasma ADMA and plasma biopterins.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for a laparoscopic inguinal hernia repair
- •Patients ≥ 18 years old
排除标准
- •Not capable of giving informed consent after oral and written information
- •Previously included in the trial  - Surgery within 7 days of the trial
结局指标
主要结局
Change in endothelial function assessed by the EndoPat system
时间窗: At baseline and 4 hours postoperatively
次要结局
- Change in biomarkers of endothelial function: plasma arginine, plasma ADMA, plasma biopterins(At baseline and 4 hours postoperatively)
研究者
Sarah Victoria Ekeløf Busch
MD
Zealand University Hospital