Kinetics of extracellular vesicles in hemodialysis

Recruiting

• Conditions: Tissue injury and bio-incompatibility in hemodialysis; 10038430

• Registration Number: NL-OMON53277
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 6

Inclusion Criteria

- Age >= 18 years - Stable clinical situation: free of infection, no recent
admission - Treatment with HD >3 months - Haemoglobin level >= 6,2 mmol/L -
Residual diuresis <200mL/24h - Willing and able to give written informed
consent

Exclusion Criteria

- Active infection, malignancy, auto-immune disease, or treatment with
immunosuppressive medication. - Allergy to polysulfone dialyzers - Life
expectancy <3 months due to non-renal disease - No access recirculation

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Concentration of EVs in peripheral blood (i. e. CD45, CD61, CD62e, CD62p,<br /><br>CD235, CD62e, CD144, Connexin-43)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>