Postoperative Assessment in TMJ Surgery: A Comparison of the Efficacy of Intraoperative Platelet-Rich Plasma and Platelet-Rich Fibrin Injections
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 700
- 试验地点
- 1
- 主要终点
- pain intensity
研究概览
简要总结
The goal of this observational study is to evaluate postoperative outcomes following temporomandibular joint (TMJ) surgery and to compare the effectiveness of intraoperative platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) injections in patients with temporomandibular joint disorders.
The study includes adult patients who underwent TMJ surgery and received either PRP or PRF intraoperatively. The main questions this study aims to answer are:
Whether intraoperative PRP or PRF injection is associated with differences in postoperative pain intensity and recovery.
Whether PRP and PRF differ in their effects on postoperative jaw function, including maximum mouth opening and joint symptoms.
If there is a comparison group: Researchers will compare patients who received intraoperative PRP with those who received intraoperative PRF to assess differences in postoperative pain, functional outcomes, and joint-related symptoms.
Participants will:
Have their existing medical records reviewed retrospectively.
Provide postoperative outcome data derived from routine clinical follow-up, with no prospective recruitment or intervention.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 18 to 75 years (inclusive)
- •Underwent unilateral or bilateral temporomandibular joint (TMJ) arthroscopy
- •Received intraoperative platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) injection during TMJ arthroscopy
排除标准
- •Age younger than 18 years or older than 75 years
- •Did not undergo TMJ arthroscopy
- •Did not receive intraoperative PRP or PRF injection
- •Incomplete clinical or follow-up data
研究组 & 干预措施
Group 1 - Platelet-Rich Plasma injection therapy group
Patients who received Platelet-Rich Plasma injections during surgery.
Group 2 - Platelet-Rich Fibrin injection therapy group
Patients who are receiving Platelet-Rich Fibrin injections during surgery.
Group 3 - non injection therapy group
Patients who are not receiving Platelet-Rich Plasma nor Platelet-Rich Fibrin injections during surgery.
结局指标
主要结局
pain intensity
时间窗: from baseline to 6 months post-surgery.
The primary endpoint of the study is the change in pain intensity from baseline to 6 months post-surgery.
次要结局
- maximum unassisted opening (MMO)(baseline and various follow-up times in 6 months.)
研究者
Jingping Wang, MD, Ph.D.
Associate Professor Staff Anesthesiologist & Pain Physician
Massachusetts General Hospital