A Cross-sectional Study on the Association of Peptidoglycan Fragments Derived From Gut Microbiota With Colorectal Cancer
Recruiting
- Conditions
- Colorectal Cancer
- Interventions
- Other: observational study, no intervention
- Registration Number
- NCT06379412
- Lead Sponsor
- Zhujiang Hospital
- Brief Summary
The goal of this observational study is to explore the association of peptidoglycan fragments derived from gut microbiota with colorectal cancer (CRC). The main question it aims to answer is: Are peptidoglycan fragments from the gut microbiota associated with the progression of colorectal cancer? Participants will provide biological specimens (blood, feces, colon tissue obtained during surgery)
- Detailed Description
To explore whether peptidoglycan fragments can be used as screening or diagnostic indicators for colorectal cancer
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
- People who underwent total colonoscopy in gastroenteroscopy room.
- People who agree to participate in this study and are willing to sign informed consent.
Exclusion Criteria
- Previous diagnosis of malignant tumors other than colorectal cancer.
- Received any of the following drug treatments within 1 month before sample collection: ① Drugs used for the treatment of colorectal diseases; ② Antibiotics; ③probiotics; ④ Laxatives.
- Patients with a family history of colorectal cancer.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Colorectal polyp(CRP) observational study, no intervention People who are diagnosed with CRP by colonoscopy and pathological biopsy Colorectal Cancer(CRC) observational study, no intervention People who are diagnosed with CRC by colonoscopy and pathological biopsy Colorectal adenoma(CRA) observational study, no intervention People who are diagnosed with CRA by colonoscopy and pathological biopsy Healthy observational study, no intervention People who have no obvious abnormality in the whole colon
- Primary Outcome Measures
Name Time Method HPLC-MS/MS was used to detect peptidoglycan fragment content in biological specimens of 200 participants baseline (before treatment) The content of peptidoglycan fragments was detected by HPLC-MS/MS
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Zhujiang Hospital of Southern Medical University
🇨🇳Guangzhou, Guangdong, China