Evaluation of Alternative Transfusion Triggers in Hemodynamically Stable, Non-Ventilated Cancer Patients: A Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 107
- 试验地点
- 1
- 主要终点
- Change in Oxygen Extraction Ratio (O₂ER)
研究概览
简要总结
This is a prospective, single-center observational study conducted at the Kazakh Institute of Oncology and Radiology. The study included 107 clinically stable adult patients with cancer who required red blood cell transfusion based on a restrictive hemoglobin threshold. The aim of the study was to evaluate alternative physiological indicators of transfusion need and effectiveness. Measurements included oxygen extraction ratio (O₂ER), central venous oxygen saturation (ScvO₂), partial pressure of oxygen in central venous blood (PvO₂), arterio-venous oxygen difference (A-VO₂diff), lactate, and veno-arterial carbon dioxide difference (ΔCO₂). These parameters were assessed before and one hour after transfusion. For data analysis, patients were stratified into two groups based on their baseline O₂ER (≤35.4% and >35.4%) to evaluate whether higher O₂ER is associated with more pronounced physiological response to transfusion.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult cancer patients (age 18 years or older)
- •Hemodynamically stable
- •Not requiring any form of respiratory support
- •Presence of a central venous catheter inserted into the superior vena cava
排除标准
- •Hemodynamic instability requiring inotropic or vasopressor support
- •Active bleeding
- •Shock of any etiology
- •Patient refusal to participate in the study
- •Hematological malignancies
- •Age under 18 years
- •Pregnancy
结局指标
主要结局
Change in Oxygen Extraction Ratio (O₂ER)
时间窗: Baseline and 1 hour post-transfusion
Difference in oxygen extraction ratio measured before and one hour after red blood cell transfusion
次要结局
- Change in Partial Pressure of Oxygen in Central Venous Blood (PvO₂)(Baseline and 1 hour post-transfusion)
- Change in Central Venous Oxygen Saturation (ScvO₂)(Baseline and 1 hour post-transfusion)
- Change in Lactate Concentration(Baseline and 1 hour post-transfusion)
- Change in Arterio-Venous Oxygen Difference (A-VO₂diff)(Baseline and 1 hour post-transfusion)
- Change in Veno-Arterial Carbon Dioxide Difference (ΔCO₂)(Baseline and 1 hour post-transfusion)
研究者
Ardak Arynov
Head of the Department of Anesthesiology and Intensive Care, Kazakh Institute of Oncology and Radiology
Kazakh Institute of Oncology and Radiology