A study to determine blood levels of oral itraconazole and its correlation with clinical response in chronic fungal infection of ski
Not Applicable
- Conditions
- Health Condition 1: B359- Dermatophytosis, unspecified
- Registration Number
- CTRI/2019/09/021083
- Lead Sponsor
- Post graduate institute of medical education and research Chandigarh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All patients above the age of 18 years diagnosed clinically to have chronic dermatophytosis(excluding nail and scalp infections)
Exclusion Criteria
Pregnant and lactating mothers, patients on immunosuppressive drugs,patients with hepatitis b and c, hepatic and renal diseases with abnormal laboratories values, patient taking any drug interacting with itraconazole, per treatment with oral itraconazole and topical antifungal within 4 week and 2 week respectively,who unwilling to give written consent.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measurement of plasma itraconazole level of three different brands(innovator,multinational,domestic) to estimate the target concentrations for therapeutic efficacy of itraconazole in chronic dermatophytosisTimepoint: Measurement of plasma itraconazole level of three different brands(innovator,multinational,domestic) to estimate the target concentrations for therapeutic efficacy of itraconazole in chronic dermatophytosis at 2 weeks and 4weeks
- Secondary Outcome Measures
Name Time Method To observe any correlation between serum cortisol and clinical response to treatmentTimepoint: Cortisol measured in microgram per desiliter at base line clinical response will observe at 2 weeks, 4 weeks and 8 weeks