A clinical trial to evaluate the effectiveness of Amukkara chooranam and aya chenduram in the management of aan maladu (oligozoospermia) - A pilot study
Trial Snapshot
- Phase
- Phase 2
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- changes in the semen parameter after the medication
Study Overview
Brief Summary
Infertility is defined as the ability to achieve pregnancy after 12 months of regular unprotected intercourse, affects upto 15% of couple worldwide. Male factor solely contributes in about 20% of infertility couples or acting in conjugation with female fertility factor in 30% of infertility couples. Oligozoospermia refers specifically to the condition in which sperm concentration below the lower reference limit of 15 million sperm/mL of ejaculate. Oligozoospermia can be further classified as mild (between 10-15 million sperms/mL),moderate (between 5-10 million sperms/mL) and severe ( less than 5 million sperms/mL). According to Siddha Scholar Yugi muni symptoms like semen showing lack of sweetness, floating on water, absence of vitality & frothy micturation indicates Aan maladu [male infertility]. In Siddha, Thathu nashtam [Oligozoospermia] has not been described as a separate disease entity. There is no direct reference for the comparison of Thathu nashtam to oligozoospermia however its feature can be understood on the basis of the indirect references available in the Siddha literatures. The various nomenclature used in siddha texts in relation with Sukkilam the seventh udal thathu [physical constituent] can be compared to sperm and not semen alone since its function is reproducion. The term Thathu Rogam [vinthu vai patria 4 noi] denotes disease relating to sperm and Thathu kuraivu / Thathu pushti kuraivu denotes Oligozoospermia and hence the term Thathu nashtam can be compared to oligozoospermia of contemporary science as both are similar in terminology [oligo-low; zoospermia-spermatozoa in semen ; thathu – sperm; nashtam-lack, be deficient in].
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Masking
- None
Eligibility Criteria
- Ages
- 22.00 Year(s) to 45.00 Year(s) (—)
- Sex
- Male
Inclusion Criteria
- •1.Male infertile patients with age between 22-45 years.
Exclusion Criteria
- •1,Azoospermia-complete absence of sperm in the ejaculate
- •Aspermia-complete lack of semen
- •Necrospermia- spermatozoa in semen are dead
- •History of undescended testis
- •Inguinal hernia on physical examination.
Outcomes
Primary Outcomes
changes in the semen parameter after the medication
Time Frame: At baseline and after 3 months
Secondary Outcomes
No secondary outcomes reported
Investigators
S ESWARI
National Institute of Siddha
