The Effect of Sitting and Moderate Exercise on Plasma Triglyceride Elevation After a Meal
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Plasma Triglycerides
研究概览
简要总结
The purpose of this study is to investigate the effect of 4 days of sitting and moderate exercise on plasma triglyceride elevation after a meal.
详细描述
Subjects will undergo three weeks (two intervention, one washout) of testing during which they will participate in two conditions: 1) prolonged sitting (~14-hours/day) with a 1-hour bout of acute exercise at 65% of pre-intervention VO2max and 2) prolonged sitting (~14-hours/day) without an acute bout of exercise. During each intervention week, subjects will have 2 days of dietary and activity control, followed by 4 days during which prolonged sitting will occur. On the evening of the 4th day, subjects in the exercise group will perform the acute bout of exercise. On day 5, all subjects will undergo a lipid tolerance test to determine the body's ability to clear triglycerides from the blood as well as insulin/glucose response and substrate oxidation. Blood samples will be assayed for the previously mentioned substances and postprandial gas collection will be analyzed via indirect calorimetry.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.)
- •respiratory problems
- •musculoskeletal problems that prevent prolonged sitting or exercise
- •susceptibility to fainting
研究组 & 干预措施
Prolonged sitting with exercise
Subjects will be asked to undergo prolonged sitting (~14-hours/day) for 4 days. On the evening of day 4, they will be asked to run at 65% of VO2max for 1-hour.
干预措施: Prolonged sitting with exercise (Behavioral)
Prolonged sitting without exercise
Subjects will be asked to undergo prolonged sitting (~14-hours/day) for 4 days. Subjects will not be asked to complete the acute bout of exercise to serve as a control.
干预措施: Prolonged sitting without exercise (Behavioral)
结局指标
主要结局
Plasma Triglycerides
时间窗: 6-hours
Areas under the curve for triglyceride concentration will be calculated for hourly samples from a 6-hour lipid tolerance test
次要结局
- Plasma Insulin(6-hours)
- Plasma Glucose(6-hours)
研究者
Edward F. Coyle
Professor
University of Texas at Austin