Zonisamide in the Treatment of Essential Tremor

Not Applicable

Terminated

• Conditions: Essential Tremor
• Interventions: Drug: Zonisamide

• Registration Number: NCT00616343
• Lead Sponsor: Loma Linda University

Brief Summary

The purpose of this study is to determine if Zonisamide is effective in reducing tremors in patients with Essential Tremor.

Detailed Description

The subjects will remain on their usual medication and a baseline assessment using the Fahn Tolosa Marin tremor rating scale will be performed and will be video taped.

Study Timeline

• Study Start: 2003-06
• Study First Submitted: 2008-02-04
• Study First Submitted QC: 2008-02-13
• Study First Posted: 2008-02-15
• Primary Completion: 2012-10
• Study Completion: 2012-12
• Results First Submitted: 2014-06-12
• Status Verified: 2014-07
• Results First Submitted QC: 2014-07-16
• Last Update Submitted: 2014-07-16
• Results First Posted: 2014-07-17
• Last Update Posted: 2014-07-17

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 9

Inclusion Criteria

1. Diagnosis of Essential Tremor based on the Tremor Investigational Group criteria for definite or probable Essential Tremor.
2. Age: 18 years or over.
3. Willingness and ability to comply with the study requirements and give informed consent.

Exclusion Criteria

1. Known history of psychiatric disorder, major depression, dementia, aplastic anemia, or Stevens-Johnson syndrome.
2. Known alcohol or substance abuse in previous 12 months.
3. Positive pregnancy test.
4. Unwillingness to use adequate contraceptive methods if of childbearing potential.
5. Known allergy to sulfonamides.
6. Laboratory abnormalities prior to onset of trial.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Zonisamide	Zonisamide	-

Primary Outcome Measures

Name	Time	Method
Tremor Severity	4 weeks	PI has left the institution and we are unable to accurately assess the data from the remaining records.