Metabolic Cluster Analysis in Septic Shock Patients
Recruiting
- Conditions
- Septic Shock
- Interventions
- Other: Fluid challenge
- Registration Number
- NCT06500156
- Lead Sponsor
- Corporacion Parc Tauli
- Brief Summary
Observational study including septic shock patients within 24 hours of ICU admission, monitored with a cardiac output estimation system, with ongoing resuscitation. Hemodynamic and metabolic parameters before and after a fluid challenge (FC) will be measured.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
- Septic shock patients within the first 24 hours of ICU admission, and selected by the attending physician for performing a fluid challenge (FC) due to suspected tissue hypoperfusion (elevated lactate and/or ScvO2 < 70%).
Exclusion Criteria
- Age under 18 years old
- Uncontrolled hemodynamic instability, defined as the need for significant changes in vasopressor support (> 10% from baseline dose) within the 15-minute period prior to, and/or during the administration of fluids.
- Patients receiving continuous renal replacement therapies, since the CO values obtained from the thermodilution techniques might be potentially affected.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Septic shock Fluid challenge Septic shock patients within the first 24 hours of ICU admission, and selected by the attending physician for performing a fluid challenge (FC) due to suspected tissue hypoperfusion.
- Primary Outcome Measures
Name Time Method VO2-response 30 minutes Percentage increase in VO2 as results of the fluid challenge
- Secondary Outcome Measures
Name Time Method Mortality 28 days Mortality within the first 28 days
Organ failure 4 days Assessment of the SOFA score at day 1, 2 and 4
Trial Locations
- Locations (1)
Hospital Universitari Parc Taulí
🇪🇸Sabadell, Barcelona, Spain