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临床试验/NCT05071755
NCT05071755Unknown不适用

Gastrectomy Outcomes in Elderly Patients

Marmara University1 个研究点 分布在 1 个国家目标入组 350 人开始时间: 2021年11月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
350
试验地点
1
主要终点
Postoperative mortality

研究概览

简要总结

In this study, the investigators aimed to identify independent prognostic factors for early postoperative complications and survival in elderly patients (aged ≥65 years) with gastric cancer.

详细描述

Gastric cancer is the 5th most common type of cancer diagnosed worldwide and ranks 3rd in cancer-related deaths. Along with surgical resection, perioperative chemotherapy or chemoradiotherapy are the main treatment method. Various complications can be seen in the postoperative period, mainly pulmonary complications (13%), cardiac complications (6%), intra-abdominal abscesses (4%), and anastomotic leaks (3%). Approximately 5% of the patients die because of postoperative complications. It is known that low body mass index as a patient-specific factor is associated with postoperative complications and poor prognosis.

The incidence of gastric cancer remains relatively high and, with increasing life expectancy, the incidence of gastric cancer in elderly patients is increasing. Characteristics of elderly patients, such as reduced physiological function, poor nutritional status, and surgical trauma from radical gastrectomy, seem to result in higher postoperative morbidity, a longer length of hospital stays, increased healthcare costs, and higher postoperative mortality. Elderly patients may have a worse prognosis compared to younger patients, primarily because of the increased risk of postoperative complications. Perioperative nutritional support and preoperative rehabilitation are beneficial for elderly patients with gastric cancer and may reduce surgical complications and mortality. Although some studies in the literature state that radical surgery can be performed for those aged 80 and over, some studies have argued that complications increase in elderly patients and that surgery should be limited.

Aim of the study is to identify prognostic factors for postoperative outcomes in elderly patients who underwent surgery for gastric cancer.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
65 Years 至 100 Years(Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients aged 65 and older
  • Operable patients with histologically confirmed gastric cancer
  • Complete follow-up information

排除标准

  • Patients under 65 years of age
  • Gastric resection for non-neoplastic diseases
  • Missing follow-up information

结局指标

主要结局

Postoperative mortality

时间窗: Within 30 days after surgery

Mortality during 30 days after surgery.

Postoperative complication rate

时间窗: Within 30 days after surgery

Complications will be reported and graded according to the Clavien-Dindo classification of surgical complications.

Overall survival

时间窗: Five years

Overall survival is defined as the time interval from the time of the radical gastrectomy to the date of all-cause death or the last follow-up.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Tevfik Kivilcim Uprak

Assistant Professor

Marmara University

研究点 (1)

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