FFR guided PCI optimization directed by high-definition IVUS versus standard of care: the randomized FFR-REACT trial

Completed

• Conditions: coronary artery narrowing; coronary artery stenosis; 10003216

• Registration Number: NL-OMON50576
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 640

Inclusion Criteria

1. Age >=18
2. Stable- or unstable angina or Non-ST segment elevation myocardial infarction
3. Target lesion stenosis >= 50% by visual estimation or QCA

Exclusion Criteria

1. Patients with ST-elevation myocardial infarction (STEMI) or evidence of
myocardial infarction within 72 hours before the index procedure
2. Target vessel distal reference diameter <2.25mm
3. Cardiogenic shock or severe hemodynamic instability
4. Inability to perform post procedure FFR
5. The patient has other medical illnesses (i.e., cancer) that may cause the
patient to be non-compliant with the protocol, confound the data interpretation
or is associated with limited life expectancy (i.e., less than one year).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Target vessel failure (TVF), a composite of cardiac death, target-vessel<br /><br>myocardial infarction and clinically driven TVR at 1 year.</p><br>