Intravesical Instillation of Hyaluronic Acid to Decrease Incidence of Urinary Tract Infection
- Registration Number
- NCT02034890
- Lead Sponsor
- Rabin Medical Center
- Brief Summary
Prospective trial which includes instillation of intravesical hyaluronic acid in an attempt to reduce the incidence of urinary tract infections in patients after orthotopic neobladder reconstruction.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- patients undergoing radical cystectomy and orthotopic neobladder reconstruction
Exclusion Criteria
- patients <18 years and unwilling to participate in this study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description hyaluronic acid Hyaluronic Acid intravesical instillation of 40 mg of hyaluronic acid at 6 specific time points: 1,2,3 and 4 weeks postoperatively 2 and 3 months postoperatively
- Primary Outcome Measures
Name Time Method positive urinary culture 6 months
- Secondary Outcome Measures
Name Time Method urinary tract infection 6 months
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie hyaluronic acid's effect on urothelial barrier function in neobladder patients?
How does intravesical hyaluronic acid compare to standard antibiotic prophylaxis in reducing post-neobladder UTIs?
Are there specific urothelial biomarkers that predict response to hyaluronic acid therapy in orthotopic neobladder reconstruction?
What are the potential adverse events associated with hyaluronic acid instillation in postoperative urological patients?
What combination therapies with hyaluronic acid show promise in preventing recurrent UTIs after bladder reconstruction?
Trial Locations
- Locations (1)
Urology department, Rabin Medical Center
🇮🇱Petach Tiqva, Israel
Urology department, Rabin Medical Center🇮🇱Petach Tiqva, Israel