Effect of Zinc-Biofortified Wheat on Essential Fatty Acid Metabolism in Men
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Lipidomics changes
研究概览
简要总结
The purpose of this study is to determine the effect of different dietary zinc intakes on fatty acid metabolism and other zinc biomarkers
详细描述
This research is a dietary intervention study designed to evaluate the effect of progressive changes in Zn intake on fatty acid metabolism and to correlate those changes with biomarkers of dyslipidemia and insulin resistance. The main objective is to validate plasma fatty acid metabolism as a biomarker of inadequate Zn intake in subjects consuming identical diets with specific Zn content. The relative sensitivity of some fatty acid enzyme activities will also be compared to the DNA strand breaks. In addition to the primary objectives, correlations in enzyme activity with changes in fat metabolism, namely circulating triglyceride and cholesterol, will be determined. This will enable the determination of the effect of a low Zn intake on various aspects of dyslipidemia. Similar correlational analyses will be performed with clinical measures of inflammation and insulin resistance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •willing to limit food and beverage intake to that provided by the study
- •willing to discontinue consumption of alcoholic beverages during the study
- •willing to stop zinc supplementation 4 weeks prior to start of the study
- •has an operative understanding of English
- •no plans to move from the area during the study period
排除标准
- •Chronic or acute metabolic disease
- •smoker or user of nicotine products
- •history of alcohol abuse, or use of illicit drugs.
- •Is underweight or overweight, body mass index (BMI) < 18 or > 30 kg/m2.
研究组 & 干预措施
diet zinc
3 dietary zinc levels: 6 mg/d, 11 mg/d and 25 mg supplemental zinc/d
干预措施: Diet Zinc (Other)
结局指标
主要结局
Lipidomics changes
时间窗: Day 0, day 15, day 57 and day 71
Change in Fatty acid metabolism
DNA strand breaks changes
时间窗: Day 0, day 15, day 57 and day 71
change in COMET assay olive-tail moments
次要结局
- Polar Metabolomics changes(Day 0, day 15, day 57 and day 71)
- Fat allocation changes(Day 0, day 15, day 57 and day 71)
- Mineral analysis changes(Day 0, day 15, day 57 and day 71)
- Body weight changes(Day 0, day 15, day 57 and day 71)