Role of Azithromycin in children with acute exacerbation of asthma
- Conditions
- Health Condition 1: J453- Mild persistent asthmaHealth Condition 2: J459- Other and unspecified asthmaHealth Condition 3: J459- Other and unspecified asthma
- Registration Number
- CTRI/2020/10/028478
- Lead Sponsor
- I
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
children aged 5-14 years presenting with acute exacerbation of asthma
1.Children with heart ,liver ,neurological or kidney diseases.
2.Children with evidence of pneumonia
3.Children with respiratory rate more than 50, or fever more than 39 degree Celsius.
4.Children with abnormal development of airways ,congenital respiratory tract diseases
5.Children with metabolic and autoimmune diseases.
6.Children with known Q-T interval prolongation
7.Children with macrolide allergy
8.Children taking medication which prolongs Q-T interval
9.Children using oral and systemic antibiotic within 28 days of enrollment
10.Children who needs intensive care
11.Children with history of tachyarrhythmia and /or bradyarrhythmia
12.Caregivers who are not willing to give informed written consent
13.Children with recurrent chest infections
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome will be assessed on day 4 of initial treatment by following parameters : <br/ ><br> Duration of respiratory symptoms to resolve i.e. <br/ ><br>1.Difficulty in breathing <br/ ><br>2.Fast breathing <br/ ><br>3.Noisy breathing, <br/ ><br>4.Chest tightness or chest pain <br/ ><br>5.Persistent cough <br/ ><br>6.Any adverse effect of drug like diarrohea , drug allergy , palpitation <br/ ><br>Timepoint: day of presentation , day 4th ,day 14th <br/ ><br>
- Secondary Outcome Measures
Name Time Method Detection of IgM Mycoplasma pneumonia in peripheral blood sample by ELISA method in children aged 5-14 years with acuteexacerbation of asthmaTimepoint: on day of addmission