JPRN-jRCTs031190226CompletedPhase 2
A prospective multi-center open trial to evaluate the safety and efficacy of favipiravir in patients infected with COVID-19.
Tokue Yutaka0 sites100 target enrollmentStarted: February 27, 2020Last updated:
Trial Snapshot
- Phase
- Phase 2
- Status
- Completed
- Sponsor
- Enrollment
- 100
Study Overview
Brief Summary
There was no difference in adjusted mean change in CRP between cohorts 1 and 2: -1.57 (95% CI -3.02 to -0.12) mg/dL and -2.29 (95% CI -3.77 to -0.81) mg/dL, respectively (p=0.500). The negative conversion rate of SARS-CoV-2 was higher in cohort 2 than in cohort 1 (odds ratio 2.67 (95% CI, 1.09 to 6.52), p=0.032), and a trend of greater efficacy was seen in patients with older age, lower BMI, lower baseline CRP, and without steroid use.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- >= 20age old to ot applicable (—)
- Sex
- All
Inclusion Criteria
- •positive result for COVID-19 detection test
- •fever above 37.5 degree Celsius, or pneumonia shadow on chest X-ray or CT-scan
- •hospital admission
Exclusion Criteria
- Not provided
Investigators
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