NCT03649555CompletedPhase 1
Reliability of [18F]-FTC-146 Brain Uptake in Healthy Controls
Conditions
Interventions
Drugs
Trial Snapshot
- Phase
- Phase 1
- Status
- Completed
- Sponsor
- Stanford University
- Enrollment
- 5
- Locations
- 1
- Primary Endpoint
- Reliability under test retest conditions
Study Overview
Brief Summary
The purpose of this study is to understand the reliability of [18F]-FTC-146 brain uptake in healthy controls.
Detailed Description
The purpose of this study is to understand the reliability of [18F]-FTC-146 brain uptake in healthy controls under test and retest conditions.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •either gender and all ethno-racial categories
- •capacity to provide informed consent
- •Female participants are expected to use an effective method of birth control throughout the study
Exclusion Criteria
- •Any current or lifetime psychiatric diagnosis
- •Current or past use of psychotropic medication
- •Pregnant or nursing females
- •Major medical or neurological problem
- •Presence of metal in the body that is contraindicated for MRI scans
Arms & Interventions
[18F]-FTC-146
Experimental
[18F]-FTC-146
Intervention: [18F]-FTC-146 (Drug)
Outcomes
Primary Outcomes
Reliability under test retest conditions
Time Frame: 1 week
Regional brain uptake of \[18F\]FTC-146 will be analyzed by kinetic modeling with metabolite-corrected arterial input functions to establish stability and reproducibility of \[18F\] FTC-146 VT in humans (n=6) under test and retest conditions.
Secondary Outcomes
No secondary outcomes reported
Investigators
Carolyn Rodriguez
Assistant Professor
Stanford University
Study Sites (1)
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