Double-Blind, Placebo-Controlled, Cross-Over Assessment of Intravenous Methamphetamine and Sublingual Lobeline Interactions

National Institute on Drug Abuse (NIDA)2 个研究点分布在 1 个国家目标入组 10 人开始时间: 2007年2月23日最近更新: 2017年1月11日

适应症

试验速览

阶段: 1 期
发起方: National Institute on Drug Abuse (NIDA)
入组人数: 10
试验地点: 2
主要终点: Cardiovascular responses

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The purpose of this study is to determine if there are significant cardiovascular or other interactions between sublingual lobeline and intravenous methamphetamine.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Treatment
盲法: Double

入排标准

年龄范围: 18 Years 至 45 Years（Adult）
性别: Female
接受健康志愿者: 是

入选标准

•Be between the ages of 18 and 45 years of age
•Be in general good health with a history of methamphetamine (MA) abuse (but not dependence)
•If female and of child bearing potential, agrees to use birth control
•Be able to understand and provide written informed consent
•Have a body mass index between 18 and 30
•Have reported use of (MA) during the past three months without experiencing adverse consequence plus a life time MA or amphetamine use history of at least four occasions of use
•Have a negative drug test (barbiturates, benzodiazepines, amphetamines, opiates, cocaine, cannabinoids, ethanol) at screening and at the time of admission

排除标准

•Please contact site for details

结局指标

主要结局

Cardiovascular responses

次要结局

Subjective effects

研究者

发起方

National Institute on Drug Abuse (NIDA)

申办方类型

Nih

研究点 (2)

Loading locations...

相似试验

已完成

1 期

Study to Assess Potential Interactions Between Intravenous Cocaine and Oral LorcaserinCocaine Abuse

NCT02393599National Institute on Drug Abuse (NIDA)20

已完成

3 期

A Study With Aleglitazar in Patients With a Recent Acute Coronary Syndrome and Type 2 Diabetes MellitusDiabetes Mellitus Type 2

NCT01042769Hoffmann-La Roche7,226

终止

3 期

Study of TAK-875 in Adults With Type 2 Diabetes and Cardiovascular Disease or Risk Factors for Cardiovascular DiseaseType 2 DiabetesCardiovascular Disease

NCT01609582Takeda3,207

已完成

3 期

Study to Assess Safety and Efficacy of Ticagrelor (AZD6140) Versus Clopidogrel in Asian/Japanese Patients With Non-ST or ST Elevation Acute Coronary Syndromes (ACS)Percutaneous Coronary InterventionAcute Coronary Syndrome

NCT01294462AstraZeneca801

已完成

1 期

SXC-2023 Cocaine Interaction StudyCocaine Use Disorder

NCT06343532National Institute on Drug Abuse (NIDA)19