Influence of muscle specific activation on regional glucose uptake in the human Achilles tendon - TENPET
- Conditions
- The combined forces generated by the triceps surae muscles causes non-uniform strain within the human triceps aponeuroses. This may cause non-uniform tendon force that would result in intratendinous shear strain that could possibly contribute to tendinopathy. This hypothesis has not been tested previously and therefore, we intend to use positron emission tomography to measure tendon and muscle activation with regional glucose uptake within the tendon and muscles.
- Registration Number
- EUCTR2004-004215-35-FI
- Lead Sponsor
- Turku PET Centre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- Male
- Target Recruitment
- 12
Inclusion Criteria
Men
BMI < 25 kg · m-2
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Any chronic disease
Any chronic medical defect or injury which hinder/interfere everyday life
Any regularly/periodically used medication for a disease
Previous use of anabolic steroids, additives or any other substrates
Smoking of tobacco, taking of snuffs, or use of narcotics.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: The purpose of the present study is to investigate whether isolated activation (via electrical stimulation) of an individual triceps surae muscle (medial gastrocnemius) results in region specific activity at the level of the free tendon. ;Secondary Objective: ;Primary end point(s): Primary variable in this study is glucose uptake in the tendon.
- Secondary Outcome Measures
Name Time Method