The efficacy of topical Tranexamic Acid with and without using laser laser for treatment of melasma
Phase 3
- Conditions
- melasma.Chloasma
- Registration Number
- IRCT2016011626047N1
- Lead Sponsor
- Vice chancellor for research,Tehran University of Medical Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
inclusion criteria: 18-65 years; symmetrical melasma in both half of the face; patients' satisfaction; skin type 1-5
exclusion criteria: use hidroquinone, topical and oral retinoid, topical steroid, alfa hydroxy acids and other drugs effect on pigmentation in past 4 weeks; use Oral Conterseptive Pill; chemical peeling,microderm abration, dermabratin or laser in past 3 months; history of past sensitivity to tranexamic acid; pregnancy; lactation; history ischemic or hemorrahgic events of coronal or cerebral artries
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pigmantation. Timepoint: before intervention,at the end of intervention,1 mouth and 3 mouths after end of intervention. Method of measurement: modified Melasma Area and Severity Index(mMASI) score,digital photography,patient satisfaction(questionnaire),physician assessment.
- Secondary Outcome Measures
Name Time Method Topical advers effects. Timepoint: every month in intervention period and end of intervention. Method of measurement: questionnaire and observation.