Limitation of the Ventilatory Response to Exercise in the Master Athlete

Not Applicable

Terminated

• Conditions: Healthy Volunteers
• Interventions: Other: Heliox; Other: Air

• Registration Number: NCT05307276
• Lead Sponsor: Centre Hospitalier Universitaire de Nice

Brief Summary

It is generally accepted that the ventilatory system is not a limiting factor in physical exercise in terms of performance or exercise tolerance in healthy subjects. The ventilatory system would be oversized in relation to the stresses it has to cope with, even during maximum intensity exercise. However, some highly trained endurance athletes may be exceptions to this rule. A limitation of the expiratory flow is indeed sometimes found in these athletes, whose maximum values of ventilation can confront the mechanical limits of their ventilatory system. This phenomenon could be accentuated in elderly athletes (known as "master athletes") under the effect of structural and functional pulmonary alterations that accompany aging. Our hypothesis : What is the prevalence of exercise expiratory flow limitation in the master athlete and does it cause a decrease in physical performance via an acceleration of locomotor muscle fatigue?

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-03-08
• Study First Submitted QC: 2022-03-31
• Study Start: 2022-04-01
• Study First Posted: 2022-04-01
• Primary Completion: 2023-04-01
• Study Completion: 2023-07-01
• Status Verified: 2023-09
• Last Update Submitted: 2023-09-05
• Last Update Posted: 2023-09-08

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 3

Inclusion Criteria

• Non-smoker (active or passive) or ex-smoker of less than 5 pack-years and stopped for more than 10 years.
• No known significant chronic pathology.
• No symptoms suggesting a progressive pathology.
• No contraindication to physical exercise. Normal Pulmonary Functional Test (PFT).
• Participants affiliated to the social security system

Exclusion Criteria

• Vulnerable persons as defined in Articles L. 1121-5 to L.1121-8 and L.1122-1-2 of the Public Health Code (e.g. persons deprived of liberty, minors, adults protected, etc.),
• Participants with a medical contraindication to sports practice,
• Cardiovascular, respiratory, neuromuscular and/or significant metabolic,
• Participants with declared pathology or medical treatment,
• Smoking or drug use,
• Significant chronic drug treatment,
• Lack of consent.
• Refusal to cooperate
• Recent rhino-bronchial infection (within last 4 weeks)
• Mental disability

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Healthy volunteers	Heliox	Following the selection visit (#V0) to verify the inclusion and non-inclusion criteria, participants will make 2 visits (#V1 and #V2) including in particular a Respiratory Functional Exploration (EFR) and a triangular
Healthy volunteers	Air	Following the selection visit (#V0) to verify the inclusion and non-inclusion criteria, participants will make 2 visits (#V1 and #V2) including in particular a Respiratory Functional Exploration (EFR) and a triangular

Primary Outcome Measures

Name	Time	Method
Change from baseline severity of EFL during ergocycle endurance exercise	At inclusion and 3 months	Force developed by the quadriceps muscle in response to percutaneous electrical stimulation of the femoral nerve

Secondary Outcome Measures

Name	Time	Method
Muscle activation level	At inclusion and 3 months	estimated by measuring electromyographic (EMG) activity

Trial Locations

Locations (1)

CHU de Nice; 🇫🇷 Nice, Alpes-maritimes, France