The Effects of an Anti-inflammatory Diet With or Without Curcumin Supplementation on Anthropometric Measurements, Concentrations of Thyroid Hormones, Anti-TPO, and Systemic Inflammation in Plasma and NFK-B in Peripheral Blood Mononuclear Cells in Patients With Hashimato
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Thyroid Diseases
- Sponsor
- National Nutrition and Food Technology Institute
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- LDL
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The goal of this clinical trial is to investigate The effects of an anti-inflammatory diet with or without curcumin supplementation on anthropometric measurements, concentrations of thyroid hormones, anti-TPO, and systemic inflammation in plasma and NFK-B in peripheral blood mononuclear cells in patients with Hashimoto.
The main questions it aims to answer are:
- Does prescribing an anti-inflammatory diet with or without curcumin supplementation significantly affect the changes in anthropometric measurements (weight, body mass index, BMI, waist circumference, waist-to-hip ratio) in patients with Hashimoto's disease?
- Does prescribing an anti-inflammatory diet with or without curcumin supplementation significantly affect the changes in the serum concentration of thyroid hormones (T3, T4, TSH) in patients with Hashimoto's disease?
- Does prescribing an anti-inflammatory diet with or without curcumin supplementation significantly affect the change of Anti-TPO concentration in patients with Hashimoto's disease?
- Does prescribing an anti-inflammatory diet with or without curcumin supplementation significantly affect the changes in systemic inflammation indicators (hs-CRP, IL-6) in plasma and NF-κB in peripheral blood mononuclear cells in patients with Hashimoto's disease?
Investigators
Dr Azita Hekmatdoost
MD-PHD of nutrition s science
National Nutrition and Food Technology Institute
Eligibility Criteria
Inclusion Criteria
- •Having Hashimoto's thyroiditis Willingness to cooperate Body mass index between 35 and 18.5 TSH less than ten and without clinical symptoms Not taking levothyroxine tablets
Exclusion Criteria
- •Pregnancy and breastfeeding kidney Diseases Follow non-routine weight loss diets for three months before the start of the study × Taking slimming and fat-burning drugs, fiber powder Mineral, vegetable, and fiber vitamin supplements
Outcomes
Primary Outcomes
LDL
Time Frame: 3 month
low-density lipoprotein
waist circumference
Time Frame: 3 month
waist circumference in Centimeter
HDL
Time Frame: 3 month
high-density lipoprotein
T4
Time Frame: 3 month
Thyroxine
TSH
Time Frame: 3 month
Thyroid-stimulating hormone
waist to hip ratio
Time Frame: 3 month
an Anthropometric index
IL6
Time Frame: 3 month
Interleukin 6
NF-KB
Time Frame: 3 month
Nuclear factor kappa-light-chain-enhancer of activated B cells
Anti-tpo
Time Frame: 3 month
antithyroperoxidase
Hb
Time Frame: 3 month
hemoglobin - Blood test
hs-Crp
Time Frame: 3 month
high-sensitivity C-reactive protein
hip circumference
Time Frame: 3 month
hip circumference in Centimeter
Total Cholestrol
Time Frame: 3 month
serum lipid profile
TG
Time Frame: 3 month
Triglyceride - serum lipid profile
T3
Time Frame: 3 month
Triiodothyronine
BMI
Time Frame: 3 month
Body Mass Index - Anthropometric index
hematocrit
Time Frame: 3 month
Blood test