COMPARISON BETWEEN DEXMEDETOMIDINE AND MAGNESIUM SULPHATE ON STRESS RESPONSE IN LAPAROSCOPIC CHOLECYSTECTOMY UNDER GENERAL ANAESTHESIA.

Phase 3

Not yet recruiting

• Conditions: Other postprocedural endocrine andmetabolic complications and disorders,

• Registration Number: CTRI/2020/09/027772
• Lead Sponsor: ABVIMS and Dr RML Hospital

Brief Summary

This Randomized, Comparative study between dexmedetomidine and magnesium sulphate on stress response will be conducted in the Department of Anaesthesiology, ABVIMS and Dr RML hospital, New Delhi-110001.The study will include 60 adult patients (30 in each group) undergoing laparoscopic cholecystectomy under general anaesthesia. The primary outcome of this study is to measure biochemical markers  of stress response in venous sample at specified intervals. The secondary outcome will be hemodynamic response to pneumoperitoneum seen at specified time intervals.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-10
• Last Update Posted: 2020-04-09

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

ASA grade I patients posted for elective laparoscopic cholecystectomy under general anaesthesia.

Exclusion Criteria

• 1.Hypermagnesaemia.
• 2.A known allergy to magnesium sulphate.
• 3.Any degree of heart block 4.Hypertensive or diabetic patients.
• 5.Acute cholecystitis.
• 6.Hemodynamically unstable patients 7.Pregnancy 8.BMI > 30 kg/m2.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Biochemical markers of stress response (CORTISOL, TSH, INSULIN, TNF alpha, CRP and BLOOD SUGAR)	1)baseline sample at 8 AM | 2)intra operative- 20 minutes after pneumoperitoneum | 3)4 hours after reversal of anaesthesia | 4)24 hours after reversal of anaesthesia.

Secondary Outcome Measures

Name	Time	Method
Hemodynamic response to pneumoperitoneum (HR, MAP, RR, SpO2)	Preoperative, 1 minute, 5 minutes and 20 minutes after creating pneumoperitoneum.

Trial Locations

Locations (1)

ABVIMS and Dr RML Hospital; 🇮🇳 Delhi, DELHI, India

ABVIMS and Dr RML Hospital

🇮🇳Delhi, DELHI, India

Dr Shivam Jaisawal

Principal investigator

7873657121

shivamjaiswal88@gmail.com