Early Follicular GnRH Antagonist Supplementation Improves Fertilization and Embryo Cleavage Rates in IVF-ET GnRH Antagonist Cycles
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- pregnancy rates
研究概览
简要总结
Our goal was to investigate whether early follicular supplementation of the GnRH antagonist to the flexible GnRH antagonist protocol, has a potential to improve IVF-ET clinical results
详细描述
GnRH antagonist offers many advantages when used in IVF-ET treatment, however, it is suspected to yield lower pregnancy rate when compared with the long GnRH agonist protocol.
Our goal was to investigate whether early follicular supplementation of the GnRH antagonist to the flexible GnRH antagonist protocol, has a potential to improve IVF-ET clinical results.
Consecutive patients are prospectively enrolled and randomly assigned to the study and control groups. Patients with low ovarian reserve or with uterine distortion are excluded from the study. Both groups are treated with recombinant FSH and the flexible GnRH antagonist protocol. Women in the study group are also treated with additional GnRH antagonist 0.25 mg/day on day 1, 2 and 3 of the menstrual cycle.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •infertility
- •IVF candidate
- •failure of previous IVF attempt
排除标准
- •low ovarian reserve
- •untreated distortion of uterine cavity
- •medical contraindication for IVF treatment
研究组 & 干预措施
1
Standard Flexible antagonist protocol Addition of Ganirelix at first 3 days of the cycle
干预措施: Ganirelix (Drug)
结局指标
主要结局
pregnancy rates
时间窗: one cycle
次要结局
- differences in hormonal levels(one cycle)
- differences in the basic treatment doses(one cycle)
- oocyte counts(one cycle)
- fertilization rate(one cycle)
- cleavage rate(one cycle)