Accuracy of Different Biomarkers for Predicting Delirium in Older Adults With Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- the sensitivity and specificity of different biomarkers of delirium in heart failure older patient
研究概览
简要总结
Biomarkers such as Systemic Immune-Inflammation Index (SII) and TG/Glucose Ratio (TyG) have shown promise in predicting delirium, reflecting the roles of inflammation and metabolic disturbances in its pathophysiology. This study aims to compare the predictive value of SII and the TyG ratio among other chemical and physiological biomarkers for diagnosing delirium and detecting its severity in older adults with heart failure. These biomarkers reflect different pathophysiological pathways implicated in delirium, including inflammation, cardiovascular stress, and metabolic dysfunction. By evaluating their individual and combined predictive abilities, this research seeks to identify potential tools for early identification of patients at high risk for delirium
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Heart failure stage C
排除标准
- •cognitive impairment
- •Major Neurological Conditions: (e.g., stroke, traumatic brain injury).
- •Hematological diseases that affect platelet, neutrophil, and lymphocyte counts.
- •Cardiogenic Shock
- •Ongoing Treatment with Immunosuppressants, or corticosteroids
结局指标
主要结局
the sensitivity and specificity of different biomarkers of delirium in heart failure older patient
时间窗: Within 24 hours of hospital admission
assess sensitivity and specificity of the systemic inflammatory index (SII), Rate Pressure Product (RPP), and TG/glucose ratio in predicting delirium
次要结局
- in hospital morbidity(From enrollment to the hospital discharge about 6 weeks)
- In hospital mortality(From enrollment to hospital discharge about 6 weeks)