Prospective Double-blinded Randomized Controlled Trial of 12-weeks High Dose Rabeprazole (Pariet) in the Treatment of Reflux Laryngitis in Chinese Patients
Not Applicable
Completed
- Conditions
- LaryngitisGastroesophageal Reflux
- Registration Number
- NCT00517114
- Lead Sponsor
- Hospital Authority, Hong Kong
- Brief Summary
The purpose of this study is to evaluate the efficacy of rabeprazole (pariet) versus placebo in treating reflux laryngitis in Chinese patients. Patients who attend the voice clinic of Department of ENT, Queen Mary hospital with suspected reflux laryngitis will be recruited. A questionnaire will be administered by the research assistant of the Department of Medicine and ENT, Queen Mary hospital. A 12-week course of PPI versus placebo trial will be commenced and patients' symptoms and signs will be documented at 6-week and 12-week time. The study will finish after a 12-week course of rabeprazole.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
- Ambulatory patients with age between 18-80 years old
- Patients with newly presented laryngitis.
Exclusion Criteria
- They were under 18 or over 80 years of age
- Has significant concomitant medical disease
- Pregnancy or lactating women
- Chronic cough attributable to known chronic pulmonary or tracheobronchial disease
- Previous glottal surgery, radiotherapy or malignancy
- Acid suppressive therapy within 4 wk prior to recruitment
- Pharyngo-laryngeal infection in the previous 3 months
- Tracheal intubation in previous 12 months
- Immunosuppression and use of inhaled corticosteroid
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Symptoms assessment, quality of life. 12 weeks
- Secondary Outcome Measures
Name Time Method Compliance 4 weeks Adverse effects 4 weeks
Trial Locations
- Locations (1)
Queen Mary Hospital
🇨🇳Hong Kong, China