Skin Wetting in Burn Survivors
- Conditions
- Burn Injury
- Interventions
- Other: Whole body coolingOther: Non-cooling
- Registration Number
- NCT06529757
- Lead Sponsor
- University of Texas Southwestern Medical Center
- Brief Summary
This project will identify the efficacy of whole body skin wetting aimed to attenuate excessive elevations in internal body temperatures during physical activity in well-healed burn survivors. The investigators will conduct a randomized crossover design study. Non-burned control subjects, subjects who experienced burns covering \~20% to 40% of their body surface area, and subject having burns \>40% of their body surface area will be investigated. Subjects will exercise in heated environmental conditions while receiving no cooling or whole body skin wetting.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 40
Non-burn survivors
- Healthy male and female subjects
- 18-65 years of age.
- Free of any underlying medical conditions
Exclusion Criteria (non-burned individuals):
- Any burn-related injuries resulting in at least one night of hospitalization.
- Heart disease or any other chronic medical condition requiring regular medical therapy including cancer, diabetes, and hypertension.
- Abnormalities detected on routine screening
- Individuals who participate in a structured aerobic exercise training program at moderate to high intensities.
- Current smokers, as well as individuals who regularly smoked within the past 3 years.
- Body mass index of greater than 30 kg/m^2.
- Pregnant individuals
Inclusion Criteria (burn survivors):
- Healthy male and female subjects
- 18-65 years of age.
- Free of any underlying medical conditions
- Having a burn injury covering 20-40% or >40% of the participant's body surface area; at least 50% of those burn injuries must be full thickness that required skin grafting.
- Participants must have been hospitalized due to the burn injury for a minimum of 15 days
Exclusion Criteria (burn survivors):
- Any burn-related injuries resulting in at least one night of hospitalization.
- Heart disease or any other chronic medical condition requiring regular medical therapy including cancer, diabetes, and hypertension.
- Abnormalities detected on routine screening
- Individuals who participate in a structured aerobic exercise training program at moderate to high intensities.
- Current smokers, as well as individuals who regularly smoked within the past 3 years.
- Body mass index of greater than 30 kg/m^2.
- Pregnant individuals
- Extensive unhealed injured skin
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Hot and Dry Environment_whole body skin wetting Whole body cooling Subjects will exercise for 60 minutes in a hot and dry environment while being exposed to whole body skin wetting. Hot and Dry Environment_no cooling Non-cooling Subjects will exercise for 60 minutes in a hot and dry environment while being exposed to no cooling.
- Primary Outcome Measures
Name Time Method Core Temperature Prior to and throughout the bout of exercise; an average of 90 minutes. During exercise, one's core body temperature will increase. This device will measure this increase in core body temperature throughout the exercise.
- Secondary Outcome Measures
Name Time Method Mean Skin Temperature Prior to and throughout the bout of exercise; an average of 90 minutes. Average skin temperature from six sites.
Rate Pressure Product Prior to and throughout the bout of exercise; an average of 90 minutes. Obtained from heart rate and systolic blood pressure.
Whole body sweat rate Before and after exercise. 2 min per measure. Whole body sweat rate will be measured from pre and post nude body mass measures.
Trial Locations
- Locations (1)
Institute for Exercise and Environmental Medicine
🇺🇸Dallas, Texas, United States