Cognitive Engagement and Aging Mind: A Randomized Control Trial to Determine the Effects of Adaptive Real-time Strategy Game Training on Cognition and Brain Functions of Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 58
- 试验地点
- 1
- 主要终点
- Immediate change in the composite score of executive functions
研究概览
简要总结
The purpose of this research is to examine whether and to what extent training of different types of cognitive engagement will improve performance on fluid cognitive abilities that typically decline with age. The research covered by this protocol will use behavioral data that yield response latencies and accuracies of the untrained tasks, and brain activations in fMRI tasks, to test specific hypotheses about neural plasticity and cognitive plasticity from these engagement techniques. Hence, human subjects will be employed in an experiment lasting for 20 hours spanning over 2 months where they will either receive real-time strategy-based videogame training or crystallized intelligence training. In addition, long-term retention data will be obtained after 6 month post-training to investigate any long-term benefits.
详细描述
The purpose of this research is to examine whether and to what extent training of different types of cognitive engagement will improve performance on fluid cognitive abilities that typically decline with age (such as, speed of information processing, working memory capacity, episodic memory, and executive functions). The research covered by this protocol will use behavioral data that yield response latencies and accuracies of the untrained tasks, and brain activations in fMRI tasks, to test specific hypotheses about the extent of transfer, if any, and the underlying cognitive constructs that may be trained in the process. Hence, human subjects will be employed in an experiment lasting for 20 hours spanning over 2 months where they will either receive real-time strategy-based videogame training or crystallized intelligence training. In addition, long-term retention data will be obtained after 6 month post-training to investigate any long-term benefits.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Right-handed
- •over 50 Years of Age
- •native or fluent English speaker
- •not Color-blind
- •Magnetic Resonance Imaging eligible
- •Mini Mental Status Examination Score >24
排除标准
- •Left-handed or ambidextrous
- •younger than 50
- •cannot distinguish colors during color blindness test
- •claustrophobia
- •metal artifact in body
- •over 300 lb
- •pacemaker
- •MMSE score lower than 24
- •history of stroke
- •history of substance or alcohol abuse
- •currently taking anti-psychotic or anti-depression medication
研究组 & 干预措施
Real-time strategy-based videogame training
Participants played a real-time strategy-based videogame in laboratory setting, Rise of Nations, for 2 hours a day, two days per week, for 5 weeks.
干预措施: Real-time strategy-based videogame training (Behavioral)
Crystallized intelligence training
Participants completed a series of crossword puzzles each week, for 5-6 weeks. Training sessions were completed at the participants' home or area of preference. Participant received a periodic phone call (2 times per week) from research staff to update any notes or details regarding participants' study progress.
干预措施: Semantic Knowledge training (Behavioral)
结局指标
主要结局
Immediate change in the composite score of executive functions
时间窗: 9-11 weeks
Change in the composite score of executive functions, and its subcomponents, from baseline to post-training. Higher change in score represents better outcome.
Immediate change in the composite score of episodic memory
时间窗: 9-11 weeks
Change in the composite score of episodic memory from baseline to post-training.Higher change in score represents better outcome.
Immediate change in brain activations during executive functions: working memory updating
时间窗: 9-11 weeks
Change in fMRI brain activations from baseline to post-training.
Immediate change in brain activations during executive functions: multi-tasking
时间窗: 9-11 weeks
Change in fMRI brain activations from baseline to post-training.
次要结局
- Immediate change in the composite score of working memory capacity(9-11 weeks)
- immediate change in the composite score of cognition(9-11 weeks)
- Immediate change in the fluid reasoning measure(9-11 weeks)