Evaluation of a Rapid Salivary Test in Patients with Periodontitis with and without Sistemic Diseases

Not Applicable

• Conditions: Diabetes Mellitus; Rheumatoid Arthritis; Periodontitis; Stomatognathic Diseases

• Registration Number: RBR-2qbpczv
• Lead Sponsor: niversidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto

Brief Summary

Science, in recent years, has been proving the relationship between periodontal and systemic diseases, such as Diabetes Mellitus and Rheumatoid Arthritis. Therefore, early detection of periodontitis is important. There are increasingly more accurate diagnostic methods that bring less discomfort to the patient, which also encourages Periodontics to seek more effective and advantageous ways to analyze Periodontal Diseases, considering that clinical periodontal exams do not have the capacity to diagnose active disease with complete accuracy. Thus, studies propose saliva as a potential diagnostic material, as its composition contributes to the diagnosis of inflammation, mainly due to the presence of biomarkers related to Periodontal Disease. The present study proposes the evaluation of a diagnostic kit prototype for salivary total protein chair-side testing, as a complementary clinical examination, for the diagnosis and monitoring of the treatment effect. Patients (n=57) were divided into six groups: healthy patients (n=14), patients with periodontal disease (n=11), patients with periodontal health and Diabetes (n=5), patients with periodontal disease and Diabetes (n=10), patients with periodontal health and Rheumatoid Arthritis (n=5) and patients with periodontal disease and Rheumatoid Arthritis (n =12). Collection of non-stimulated saliva, prophylaxis, oral hygiene instructions and basic periodontal treatment were performed in all groups. The criteria used for clinical evaluation were gingival index, visible plaque index, probing depth, clinical attachment level and bleeding on probing. Clinical parameters were evaluated at times 0 and 45, with basic periodontal treatment on time 0. The significance level used for statistical analysis was 0.05. Regarding the correlation between the differences obtained with the salivary test, gingival index and bleeding on probing index, the gingival index variation was detected by the salivary test (p<0.05). Despite the limitations faced throughout the study, the salivary test has the potential to help customize the therapeutic approach, as a complementary clinical examination, serving as a visual model for the patient to perceive their evolution throughout the treatment, and to validate the improvement of the clinical parameters in a practical and accessible quantitative way, for professionals.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2022-10-05
• Study Start: 2023-02-23
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Minimum of 14 natural teeth (at least 10 posterior); periodontitis diagnosis; Systemically healthy patients; patients diagnosed with diabetes or rheumatoid artrhitis

Exclusion Criteria

Smoking, pregnancy; total edentulism; recent periodontal treatment; recent use of antibiotics; patients who refused to sign the Consent Form

Study & Design

• Study Type: Intervention
• Study Design: Not specified