Serum 25-Hydroxyvitamin D and Neurological Disability in Multiple Sclerosis: A Cross-Sectional Study From the Mediterranean Epidemiological Frontier
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 369
- 试验地点
- 1
- 主要终点
- EDSS
研究概览
简要总结
Vitamin D is hypothesized to play a role in the immunopathology and progression of multiple sclerosis (MS), yet its association with neurological disability remains uncertain, particularly in North African populations.We conducted a cross-sectional study involving 369 adult MS patients across two tertiary neurology centers in Western Libya. Serum 25-hydroxyvitamin D [25(OH)D] levels and Expanded Disability Status Scale (EDSS) scores were collected. Pearson correlation, ANOVA, and multivariable linear regression were used to assess associations between vitamin D and disability, adjusting for age, BMI, disease duration, and physical activity. Missing data and outliers were handled systematically using validated R and Python workflows.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Libyan nationals.
- •aged 18 years or older.
- •diagnosis of MS based on the 2017 revised McDonald criteria.
- •capable of providing informed consent.
- •had complete clinical, demographic, and biochemical data.
排除标准
- •presence of other neurological disorders that could mimic MS (e.g., neuromyelitis optica spectrum disorder or Lyme disease).
- •missing or incomplete medical records.
- •pregnancy or lactation.
- •extreme psychiatric or cognitive impairment.
结局指标
主要结局
EDSS
时间窗: 24 months
interaction between levels of Vit D and EDSS
Serum 25-Hydroxyvitamin D
时间窗: 24 months
levels of Vit D
次要结局
未报告次要终点