Serum 25-Hydroxyvitamin D and Neurological Disability in Multiple Sclerosis

Completed

• Conditions: Multiple Sclerosis

• Registration Number: NCT07123337
• Lead Sponsor: University of Zintan

Brief Summary

Vitamin D is hypothesized to play a role in the immunopathology and progression of multiple sclerosis (MS), yet its association with neurological disability remains uncertain, particularly in North African populations.We conducted a cross-sectional study involving 369 adult MS patients across two tertiary neurology centers in Western Libya. Serum 25-hydroxyvitamin D \[25(OH)D\] levels and Expanded Disability Status Scale (EDSS) scores were collected. Pearson correlation, ANOVA, and multivariable linear regression were used to assess associations between vitamin D and disability, adjusting for age, BMI, disease duration, and physical activity. Missing data and outliers were handled systematically using validated R and Python workflows.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-08-01
• Primary Completion: 2025-02-15
• Status Verified: 2025-04
• Study Completion: 2025-04-08
• Study First Submitted: 2025-08-07
• Study First Submitted QC: 2025-08-07
• Last Update Submitted: 2025-08-07
• Study First Posted: 2025-08-14
• Last Update Posted: 2025-08-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 369

Inclusion Criteria

• Participants who were Libyan nationals aged 18 years or older, had a clear diagnosis of MS based on the 2017 revised McDonald criteria [18], were capable of providing informed consent, and had complete clinical, demographic, and biochemical data were eligible for enrollment.

Exclusion Criteria

• Exclusionary factors included non-Libyan nationality, presence of other neurological disorders that could mimic MS (e.g., neuromyelitis optica spectrum disorder or Lyme disease), missing or incomplete medical records, pregnancy or lactation, and extreme psychiatric or cognitive impairment that would compromise self-reporting accuracy or clinical evaluation.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
EDSS	24 months	interaction between levels of Vit D and EDSS
Serum 25-Hydroxyvitamin D	24 months	levels of Vit D

Trial Locations

Locations (1)

Faculty of medicine zintan university; 🇱🇾 Tripoli, Libyan Arab Jamahiriya